Treatment With Bempedoic Acid and/or Its Fixed-dose Combination With Ezetimibe in Primary Hypercholesterolemia or Mixed Dyslipidemia

Recruiting

• Conditions: Hypercholesterolemia; Mixed Dyslipidemia
• Interventions: Drug: Bempedoic acid and/or its fixed-dose combination with ezetimibe

• Registration Number: NCT04579367
• Lead Sponsor: Daiichi Sankyo Europe, GmbH, a Daiichi Sankyo Company

Brief Summary

The primary objective is to describe in the real-world setting patient characteristics and outcomes of patients with primary hypercholesterolaemia (heterozygous familial and non-familial) or mixed dyslipidaemia using bempedoic acid and/or its fixed-dose combination with ezetimibe in managing plasma levels of low-density lipoprotein cholesterol (LDL-C).

Secondary objectives are to document and evaluate as applicable:

* Assessment of the cardiovascular risk of patients treated with bempedoic acid and/or its fixed-dose combination with ezetimibe using different risk scores (e.g. Systematic Coronary Risk Estimation (SCORE) system, SMART score for Very High Risk patients and Framingham risk score for High Risk patients. The scores will be re-calculated during the analysis and used as an analytical tool only).

* Changes in low-density lipoprotein cholesterol (LDL-C) levels prior to treatment with bempedoic acid and/or its fixed-dose combination with ezetimibe compared to 1 year follow-up and subsequent data collection points, if applicable.

* Characterize plasma levels of other potentially ASCVD-modifying cholesterol fragments, namely, LDL-C, total cholesterol (TC), apolipoprotein B (apoB), high-density lipoprotein cholesterol (HDL-C), non-HDL-C, triglycerides (TGs) and lipoprotein A (Lp\[a\]) compared to 1 year follow-up and subsequent data collection points, if applicable.

* Changes in the levels of inflammatory marker hsCRP compared to 1 year follow-up and subsequent data collection points, if applicable.

* Adverse Drug Reactions associated to bempedoic acid and/or its fixed-dose combination with ezetimibe.

* Changes in uric acid levels compared to 1 year follow-up and subsequent data collection points, if applicable.

* Relevant CV events:

* Myocardial infarction

* Unstable angina

* Coronary artery bypass graft surgery (CABG)

* Percutaneous transluminal coronary angioplasty (PTCA)

* Stroke

* Transient ischemic attack (TIA)

* Acute peripheral arterial occlusion

* All-cause death

* Cardiovascular (CV)-death

* Adverse effects associated with lipid-modifying treatment (LMT)

* Laboratory abnormalities

* Muscle-associated symptoms

* New onset and/or worsening diabetes

* Changes in the patients´ glycemic status over time

* Site characteristics (sites and practitioners) caring for patients treated with bempedoic acid and/or its fixed-dose combination with ezetimibe.

* Use of LMTs prior or concomitantly to receiving bempedoic acid and/or its fixed-dose combination with ezetimibe (therapies including combination treatments).

* Bempedoic acid and/or its fixed-dose combination with ezetimibe treatment parameters such as treatment duration by therapy, dosage, prescription intervals, permanent discontinuations, switches and reasons for these, (concomitant medication, additional therapy/interventions).

* Healthcare resource use especially consultation visits with specialist, nurse time and hospitalizations as well as patient-reported outcome using EQ-5D-5L and PAM-13.

Detailed Description

This non-interventional study will be conducted to characterize the risks and benefits of bempedoic acid and/or its fixed-dose combination with ezetimibe in a real-world clinical setting in adult patients with primary hypercholesterolaemia or mixed dyslipidaemia and to gain insight into the effectiveness (managing plasma levels of low-density lipoprotein cholesterol) as well as safety (clinical events associated with the treatment modalities). Real world evidence will be collected in 5000 participants, treated by specialized as well as non-specialized physicians in hospitals and office based centers.

Study Timeline

• Study First Submitted: 2020-10-01
• Study First Submitted QC: 2020-10-01
• Study First Posted: 2020-10-08
• Study Start: 2021-01-15
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-07
• Last Update Posted: 2025-05-13
• Primary Completion: 2025-09-01
• Study Completion: 2025-09-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 5000

Inclusion Criteria

• Written informed consent to participate
• At least 18 years of age
• Participants suffering from documented primary hypercholesterolemia or mixed dyslipidemia treated or intended to be treated with bempedoic acid and/or its fixed dose combination with ezetimibe at the discretion of the physician are appropriate for participation in the observation.
• No contraindications exist according to the SmPC of bempedoic acid and/or its fixed-dose combination with ezetimibe
• No concurrent participation in an interventional study (simultaneous participation in other non-interventional study is possible)
• Life expectancy > 1 year

Exclusion Criteria

• As this is a non-interventional study, no explicit exclusion criteria are defined. The prescribing behavior will not be influenced. Only patients will be included where the decision has been made by the treating physician to treat the patients either with bempedoic acid and/or its fixed-dose combination with ezetimibe.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Bempedoic acid and/or fixed-dose combination with ezetimibe	Bempedoic acid and/or its fixed-dose combination with ezetimibe	Participants with primary hypercholesterolemia or mixed dyslipidemia who received bempedoic acid and/or its fixed-dose combination with ezetimibe.

Primary Outcome Measures

Name	Time	Method
Summary of patient characteristics in patients with primary hypercholesterolemia or mixed dyslipidemia following treatment with bempedoic acid and/or its fixed-dose combination with ezetimibe	Baseline (date of signed informed consent) up to 1 year minimum or 2 year maximum follow up (depending on the availability of bempedoic acid in countries)

Secondary Outcome Measures

Name	Time	Method
Overview of the cardiovascular risk of patients with primary hypercholesterolemia or mixed dyslipidemia following treatment with bempedoic acid/ and/or its fixed-dose combination with ezetimibe	Baseline (date of signed informed consent) up to 1 year minimum or 2 year maximum follow up (depending on the availability of bempedoic acid in countries)	Cardiovascular risk scores will be assessed using the Systematic Coronary Risk Estimation (SCORE) system, Second manifestations of arterial disease (SMART) and Framingham risk scores. The SMART risk score will estimate 10-year risk for very high-risk participants based on clinical patient characteristics. The gender-specific Framingham risk score will be used to estimate 10-year cardiovascular risk for high-risk participants.
Summary of changes in plasma low-density lipoprotein cholesterol levels following treatment with bempedoic acid and/or its fixed-dose combination with ezetimibe in patients with primary hypercholesterolemia or mixed dyslipidemia	Baseline (date of signed informed consent) up to 1 year minimum or 2 year maximum follow up (depending on the availability of bempedoic acid in countries)
Summary in changes in plasma levels of atherosclerotic cardiovascular disease-modifying cholesterol fragments following treatment with bempedoic acid and/or its fixed-dose combination with ezetimibe	Baseline (date of signed informed consent) up to 1 year minimum or 2 year maximum follow up (depending on the availability of bempedoic acid in countries)	Plasma levels of total cholesterol (TC), apolipoprotein B (apoB), high-density lipoprotein cholesterol (HDL-C), triglycerides (TGs) and lipoprotein a (Lp\[a\]) will be assessed.
Summary of changes in plasma inflammatory marker hsCRP levels following treatment with bempedoic acid and/or its fixed-dose combination with ezetimibe in patients with primary hypercholesterolemia or mixed dyslipidemia	Baseline (date of signed informed consent) up to 1 year minimum or 2 year maximum follow up (depending on the availability of bempedoic acid in countries)	Inflammatory status was assessed using high-sensitive C-reactive protein.

Trial Locations

Locations (474)

CUB-Hôpital Erasme; 🇧🇪 Bruxelles, Belgium

Private Practice; 🇧🇪 Tienen, Belgium

Az Sint Blazius; 🇧🇪 Dendermonde, Belgium

UZ Antwerpen; 🇧🇪 Edegem, Belgium

Z.O.L - Campus St. Jan; 🇧🇪 Genk, Belgium

AZ St-Lucas & Volkskliniek; 🇧🇪 Ghent, Belgium

JAN YPERMAN Ziekenhuis; 🇧🇪 Ieper, Belgium

AZ Groeninge Kortrijk; 🇧🇪 Kortrijk, Belgium

CHU Tivoli; 🇧🇪 La Louvière, Belgium

UZ Leuven; 🇧🇪 Leuven, Belgium

CHR Citadelle de Liège; 🇧🇪 Liège, Belgium

CHU Liège; 🇧🇪 Liège, Belgium

B. Braun Ambulantes Herzzentrum Kassel; 🇩🇪 Kassel, Germany

ASZ; 🇧🇪 Aalst, Belgium

Clinique Saint-Luc Bouge Namur; 🇧🇪 Bouge, Belgium

Epicura Hornu; 🇧🇪 Boussu, Belgium

A.Z. KLINA Brasschaat; 🇧🇪 Brasschaat, Belgium

Clinique Saint-Jean Bruxelles; 🇧🇪 Bruxelles, Belgium

CHU Brugman; 🇧🇪 Bruxelles, Belgium

SRH Klinikum Karlsbad-Langensteinbach; 🇩🇪 Karlsbad, Germany

Praxis Dr. Heiner Müller; 🇩🇪 Katzhütte, Germany

Schnürer & Fritsch - Gruppenpraxis für Innere Medizin; 🇦🇹 Wien, Austria

UZ Gent; 🇧🇪 Ghent, Belgium

GHDC Charleroi - Site Hôpital Saint-Joseph; 🇧🇪 Gilly, Belgium

Pôle hospitalier Jolimont; 🇧🇪 Haine-Saint-Paul, Belgium

Nephrologie Kiel; 🇩🇪 Kiel, Germany

BVBA Med Kab; 🇧🇪 Halen, Belgium

Jessa Ziekenhuis; 🇧🇪 Hasselt, Belgium

Gemeinschaftsklinikum Mittelrhein; 🇩🇪 Koblenz, Germany

CHR Huy; 🇧🇪 Huy, Belgium

CHU Charleroi Hopital civil Marie-Curie; 🇧🇪 Lodelinsart, Belgium

CHU Mons Ambroise Paré; 🇧🇪 Mons, Belgium

UZ Brussel; 🇧🇪 Bruxelles, Belgium

AZ Sint Jan; 🇧🇪 Oostende, Belgium

Clinique de l'Europe Saint Elisabeth; 🇧🇪 Bruxelles, Belgium

Kardiologische Schwerpunktpraxis; 🇩🇪 Heidelberg, Germany

Dres. Wauer/Windstetter; 🇩🇪 München, Germany

UCL Saint-Luc Woluwé Bruxelles; 🇧🇪 Bruxelles, Belgium

Kardiologische Gemeinschaftspraxis Bremerhaven; 🇩🇪 Bremerhaven, Germany

AZ Delta; 🇧🇪 Roeselare, Belgium

AZ Glorieux; 🇧🇪 Ronse, Belgium

Hospital Vall d'Hebron; 🇪🇸 Bacelona, Spain

Sint Trudo; 🇧🇪 Sint Truiden, Belgium

Kardiologie im Friedrichspalast Bruchsal; 🇩🇪 Bruchsal, Germany

Sint-Andriesziekenhuis Tielt; 🇧🇪 Tielt, Belgium

Hospital Universitari Sant Joan; 🇪🇸 Reus, Spain

Kardiologische Praxis Stellmach; 🇩🇪 Chemnitz, Germany

Cardiologicum Dresden/Pirna; 🇩🇪 Dresden, Germany

CHU UCL Mont-Godinne; 🇧🇪 Yvoir, Belgium

Studiengesellschaft Könemann und Steinmann GbR; 🇩🇪 Bünde, Germany

MediClin Reha-Zentrum Spreewald; 🇩🇪 Burg, Germany

Downtown Clinic Aachen; 🇩🇪 Aachen, Germany

MVZ am Küchwald; 🇩🇪 Chemnitz, Germany

Praxis Delonge; 🇩🇪 Aachen, Germany

Praxis Osterziel; 🇩🇪 Amberg, Germany

MVZ Helios Aue; 🇩🇪 Aue, Germany

Kardiologische Praxis Enders; 🇩🇪 Bad Elster, Germany

MVZ Polymed; 🇩🇪 Chemnitz, Germany

Praxis Dr. Menzel; 🇩🇪 Dessau, Germany

SLK-Klinikum am Plattenwald; 🇩🇪 Bad Friedrichshall, Germany

Herzcarre Praxis; 🇩🇪 Bad Homburg, Germany

Klinikum Lippe GmbH; 🇩🇪 Detmold, Germany

Kardiologische Praxis; 🇩🇪 Markkleeberg, Germany

Corporación Sanitaria Parc Taulí; 🇪🇸 Sabadell, Barcelona, Spain

Zentrum für klinische Forschung; 🇩🇪 Köln, Germany

Universitätsklinikum Freiburg - Universitäts-Herzzentrum; 🇩🇪 Bad Krozingen, Germany

Praxis am Landratspark; 🇩🇪 Bad Segeberg, Germany

Hausärzte am Spritzenhaus; 🇩🇪 Baiersbronn, Germany

CIMS Studienzentrum Bamberg GmbH Drs. Kirschner/Haas/Ritzel; 🇩🇪 Bamberg, Germany

Kardiologische Gemeinschaftspraxis; 🇩🇪 Potsdam, Germany

Praxis Rankestraße; 🇩🇪 Berlin, Germany

Praxis Kiepenkerl; 🇩🇪 Münster, Germany

Zentrum für Kardiologie an der Raphaelsklinik Münster; 🇩🇪 Münster, Germany

SKP Studienzentrum der kardiologischen Praxisgemeinschaft Rankestrasse GmbH; 🇩🇪 Berlin, Germany

Herzpraxis Berlin MVZ; 🇩🇪 Berlin, Germany

Hausärztliche Gemeinschaftspraxis mit diabetologischem Schwerpunkt; 🇩🇪 Dresden, Germany

MVZ Prof. Mathey, Prof. Schofer; 🇩🇪 Hamburg, Germany

Kardiologie am Tibarg; 🇩🇪 Hamburg, Germany

Allgemeines Krankenhaus der Stadt Wien; 🇦🇹 Wien, Austria

Zentrum für Klinische Studien Dr. Hanusch GmbH; 🇦🇹 Wien, Austria

Univ.-Prof. Dr. Thomas Stulnig; 🇦🇹 Wien, Austria

Kardiologie List; 🇩🇪 Hannover, Germany

Herz Zentrum Währing; 🇦🇹 Wien, Austria

Dres. Günther/Kolschmann; 🇩🇪 Dresden, Germany

Karl Landsteiner Institut für kardiovaskuläre und intensivmedizinische Forschung; 🇦🇹 Wien, Austria

Centro Cardiologico Monzino; 🇮🇹 Milano, Italy

Dr. Armin Öhlinger Kardiologe & innere Medizin; 🇦🇹 Dornbirn, Austria

Landeskrankenhaus Feldkirch; 🇦🇹 Feldkirch, Austria

Institut für Herz- und Gefäßerkrankungen GmbH; 🇦🇹 Graz, Austria

LKH-Univ. Klinikum Graz; 🇦🇹 Graz, Austria

Medizinische Universität Graz; 🇦🇹 Graz, Austria

Internist Dr. med. univ. Stefan Moser; 🇦🇹 Horsching, Austria

Medizinische Universität Innsbruck; 🇦🇹 Innsbruck, Austria

KABEG Klinikum Klagenfurt am Wörthersee; 🇦🇹 Klagenfurt am Worthersee, Austria

Konventhospital der Barmherzigen Brüder Linz; 🇦🇹 Linz, Austria

Ordination Dr. Johannes Föchterle; 🇦🇹 Linz, Austria

Ordination Frau Prof. Dr. Yvonne Winhofer-Stöckl; 🇦🇹 Mattersburg, Austria

Landesklinikum Melk; 🇦🇹 Melk, Austria

Kompetenz-Zentrum Diabetes; 🇦🇹 Salzburg, Austria

Ordination Universitätsdozent Dr. Alexander Kober; 🇦🇹 Sankt Aegyd Am Neuwalde, Austria

Ordination Dr. med. univ. Evelyn Fließer-Görzer; 🇦🇹 Sankt Stefan Ob Stainz, Austria

Landeskrankenhaus Villach; 🇦🇹 Villach, Austria

Ordination Dr. Thomas Maca; 🇦🇹 Wien, Austria

Klinik Hietzing, Wiener Gesundheitsverbund; 🇦🇹 Wien, Austria

Charité - Universitätsmedizin Berlin; 🇩🇪 Berlin, Germany

Dres. Seeger & Partner; 🇩🇪 Berlin, Germany

Diabetespraxis Dr. Braun; 🇩🇪 Berlin, Germany

Lipidambulanz Charite; 🇩🇪 Berlin, Germany

Praxiszentrum Biedenkopf; 🇩🇪 Biedenkopf, Germany

Praxis Dr. A. Biedermann; 🇩🇪 Blankenhain, Germany

MVZ für Innere Medizin; 🇩🇪 Bonn, Germany

Herzzentrum Dresden, Universitätsklinik an der Technischen Universität Dresden; 🇩🇪 Dresden, Germany

Universitätsklinikum Carl Gustav Carus; 🇩🇪 Dresden, Germany

DZDM Diabeteszentrum Duisburg Mitte; 🇩🇪 Duisburg, Germany

Nierenzentrum Düren; 🇩🇪 Düren, Germany

Universitätsklinikum Düsseldorf; 🇩🇪 Düsseldorf, Germany

Praxis Dilltal; 🇩🇪 Ehringshausen, Germany

Praxis Dipl. -Med. Petra Herrmann; 🇩🇪 Eisenach, Germany

Gemeinschaftspraxis ISP Erlangen; 🇩🇪 Erlangen, Germany

Hausarztzentrum am Germaniaplatz; 🇩🇪 Essen, Germany

DIAKO Flensburg; 🇩🇪 Flensburg, Germany

Praxis für Nieren und Hochdruck-Krankheiten; 🇩🇪 Flensburg, Germany

MVZ Altstadt-Carree Fulda; 🇩🇪 Fulda, Germany

Klinikum Fulda; 🇩🇪 Fulda, Germany

Praxis Dr. Langel; 🇩🇪 Gera, Germany

Cardiocampus Gemeinschaftspraxis für Herz- und Kreislauferkrankungen; 🇩🇪 Gifhorn, Germany

Universitätsmedizin Greifswald; 🇩🇪 Greifswald, Germany

Praxis Dr. Müller; 🇩🇪 Gräfenhainichen, Germany

Praxis für Gefäßmedizin; 🇩🇪 Görlitz, Germany

Universitätsmedizin Göttingen; 🇩🇪 Göttingen, Germany

Evangelisches Krankenhaus Hagen-Haspe; 🇩🇪 Hagen, Germany

Praxis; 🇩🇪 Hainburg, Germany

Cardiologicum Hamburg - Praxis Wandsbek; 🇩🇪 Hamburg, Germany

Diabetes Zentrum Wandsbeck; 🇩🇪 Hamburg, Germany

Universitätsklinikum Heidelberg; 🇩🇪 Heidelberg, Germany

Praxis Heik/Wedig; 🇩🇪 Heiligenstadt, Germany

KARDIO-IN Kardiologische Gemeinschaftspraxis; 🇩🇪 Ingolstadt, Germany

Studienzentrum der Inneren Medizin I & II am Klinikum Konstanz; 🇩🇪 Konstanz, Germany

Kardiologie Dr. med. E. Persicke / Dr. med. O. Scheuermann; 🇩🇪 Kornwestheim, Germany

Kardiologische Praxis Kyritz; 🇩🇪 Kyritz, Germany

Uniklinik Köln; 🇩🇪 Köln, Germany

IKAPP; 🇩🇪 Köln, Germany

Universitätsklinikum Leipzig; 🇩🇪 Leipzig, Germany

Kardiologische Praxis Boudriot; 🇩🇪 Leipzig, Germany

MVZ Stoffwechselmedizin Leipzig; 🇩🇪 Leipzig, Germany

Praxis Dr. I.Simon-Wagner; 🇩🇪 Lichtenfels, Germany

St. Vincenz Krankenhaus; 🇩🇪 Limburg, Germany

Gemeinschaftspraxis Dr. Jens Biesenbaum und Dr. Uwe Gerbaulet; 🇩🇪 Lohne, Germany

Cardio Centrum Ludwigsburg-Bietigheim; 🇩🇪 Ludwigsburg, Germany

Kardiologische Praxisklinik Ludwigshafen; 🇩🇪 Ludwigshafen, Germany

Universität zu Lübeck; 🇩🇪 Luebeck, Germany

Kardiologische Praxis Tamm/Hoh; 🇩🇪 Lutherstadt Wittenberg, Germany

Institut für Präventive Medizin & Klinische Forschung GbR; 🇩🇪 Magdeburg, Germany

Cardiopraxis Mainz; 🇩🇪 Mainz, Germany

Katholisches Klinikum Mainz; 🇩🇪 Mainz, Germany

Universitätsklinikum Mainz; 🇩🇪 Mainz, Germany

ZE:RO Praxen; 🇩🇪 Mannheim, Germany

UMM Mannheim; 🇩🇪 Mannheim, Germany

Praxis Ben-Chur; 🇩🇪 Meiningen, Germany

Praxis Haj-Yehia; 🇩🇪 Moers, Germany

Gemeinschaftspraxis Dr. Prohaska/Dr. Schulte; 🇩🇪 Mühldorf, Germany

Kardiologie Mühldorf am Inn; 🇩🇪 Mühldorf, Germany

Herzquartier Mülheim; 🇩🇪 Mülheim an der Ruhr, Germany

Kardiologie Neuhausen-Nymphenburg; 🇩🇪 München, Germany

Praxis für Innere Medizin Münster; 🇩🇪 Münster, Germany

Universitätsklinikum Münster; 🇩🇪 Münster, Germany

Internistische Praxisgemeinschaft; 🇩🇪 Neu Isenburg, Germany

Kardiologische Praxis Northeim; 🇩🇪 Northeim, Germany

Hausarztpraxis; 🇩🇪 Oer-Erkenschwick, Germany

St. Vincenz-Krankenhaus GmbH; 🇩🇪 Paderborn, Germany

Kardiologische Praxis Papenburg - Site 6071; 🇩🇪 Papenburg, Germany

Kardiologische Praxis Papenburg - Site 6072; 🇩🇪 Papenburg, Germany

Gemeinschaftspraxis Dres. med. Karl-Heinz Göttl - Omar Adjan; 🇩🇪 Passau, Germany

Hausärztlich-Kardiologisches MVZ "Am Felsenkeller" GmbH; 🇩🇪 Pirna, Germany

Kinikum Ernst von Bergmann; 🇩🇪 Potsdam, Germany

VieSante Herzmedizin Potsdam; 🇩🇪 Potsdam, Germany

Allgemeinmedizinisch Internistische Praxis Dr. H. Borgmann; 🇩🇪 Radebeul, Germany

Internistisch hausärtzliche Gemeinschaftspraxis Dr. Hildebrandt & Dr. Mutscher; 🇩🇪 Radebeul, Germany

Gemeinschaftspraxis Herz Riesa; 🇩🇪 Riesa, Germany

Universitätsmedizin Rostock; 🇩🇪 Rostock, Germany

MVZ Schwerin West GmbH; 🇩🇪 Schwerin, Germany

Facharztpraxis für Kardiologie und Innere Medizin; 🇩🇪 Schwäbisch Hall, Germany

Nierenzentrum Altmark; 🇩🇪 Seehausen, Germany

Zentrum für Prävention und Rehabilitation; 🇩🇪 Siegen, Germany

Klinik Singen; 🇩🇪 Singen, Germany

MEDINOS Klinik Sonneberg; 🇩🇪 Sonneberg, Germany

Kardiologische Praxis im Steiner Thor; 🇩🇪 Straubing, Germany

Praxis Dr Knöbel u. Partner; 🇩🇪 Straubing, Germany

Praxis Dr. Michael Rother; 🇩🇪 Strausberg, Germany

Diabetologische Schwerpunktpraxis; 🇩🇪 Trier, Germany

Krankenhaus der Barmherzigen Brüder Trier; 🇩🇪 Trier, Germany

Studienzentrum der Herzklinik Ulm GbR; 🇩🇪 Ulm, Germany

Praxis Dr. Hansen; 🇩🇪 Unterwellenborn, Germany

Praxis Dr. Dengler/Hohenstatt; 🇩🇪 Ursensollen, Germany

Herzzentrum Saar; 🇩🇪 Völklingen, Germany

GRN Weinheim; 🇩🇪 Weinheim, Germany

Kardiologische Praxis Al-Zoebi; 🇩🇪 Wermsdorf, Germany

Internistische Gemeinschaftspraxis Dr. med. Schreckenberg, Dr. med. Vorderstraße; 🇩🇪 Weyhe, Germany

Forschungszentrum-Ruhr / KliFoCenter GmbH; 🇩🇪 Witten, Germany

Kardiologische Fachpraxis; 🇩🇪 Wolmirstedt, Germany

Zentrum für Nieren- und Hochdrucklerkrankungen Hofaue; 🇩🇪 Wuppertal, Germany

Universitätsklinikum Würzburg; 🇩🇪 Würzburg, Germany

Gemeinschaftspraxis am Angerbrunnen; 🇩🇪 Zwiesel, Germany

Ospedale Generale Regionale "F. Miulli"; 🇮🇹 Acquaviva Delle Fonti, Italy

P.O. Agrigento Ospedale San Giovanni di Dio; 🇮🇹 Agrigento, Italy

IRCCS-INRCA Ancona; 🇮🇹 Ancona, Italy

Ospedale di Anzio; 🇮🇹 Anzio, Italy

Ospedale dei Castelli; 🇮🇹 Ariccia, Italy

Ospedale "C. e G. Mazzoni"; 🇮🇹 Ascoli Piceno, Italy

A.O. San Giuseppe Moscati; 🇮🇹 Avellino, Italy

Ospedale SS Nicola e Filippo; 🇮🇹 Avezzano, Italy

Ospedale S. Paolo; 🇮🇹 Bari, Italy

A.O.U. Consorziale - Policlinico Bari; 🇮🇹 Bari, Italy

Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari - Site 08016; 🇮🇹 Bari, Italy

Azienda Universitaria Ospedaliera Consorziale - Policlinico di Bari - Site 08017; 🇮🇹 Bari, Italy

Azienda Ospedaliera S. Pio presidio G. Rummo; 🇮🇹 Benevento, Italy

AUSL Bologna Ospedale di Bentivoglio; 🇮🇹 Bentivoglio, Italy

ASST Papa Giovanni XXIII; 🇮🇹 Bergamo, Italy

Ospedale Maggiore Carlo Alberto Pizzardi; 🇮🇹 Bologna, Italy

Policlinico Sant'Orsola Bologna-Malpighi; 🇮🇹 Bologna, Italy

Ospedale di Bolzano - Site 08070; 🇮🇹 Bolzano, Italy

Ospedale di Bolzano - Site 08112; 🇮🇹 Bolzano, Italy

Spedali Civili di Brescia; 🇮🇹 Brescia, Italy

Ospedale Santo Spirito Casale Monferrato; 🇮🇹 Casale Monferrato, Italy

A.O. S. Anna e S. Sebastiano; 🇮🇹 Caserta, Italy

ULLS 2 MARCA TREVIGIANA Ospedale di Castelfranco Veneto; 🇮🇹 Castelfranco Veneto, Italy

AOU Policlinico Vittorio Emanuele Presidio Ospedaliero Gaspare Rodolico; 🇮🇹 Catania, Italy

Azienda Ospedaliera Cannizzaro; 🇮🇹 Catania, Italy

L'Azienda Ospedaliero-Universitaria "Renato Dulbecco" di Catanzaro; 🇮🇹 Catanzaro, Italy

Ospedale Civile Santa Maria Incoronata dell'Olmo; 🇮🇹 Cava Dè Tirreni, Italy

Policlinico SS. Annunziata; 🇮🇹 Chieti, Italy

ASL TO4 Presidio Riunito di Ciriè-Lanzo; 🇮🇹 Ciriè, Italy

Azienda Ospedaliero-Universitaria di Ferrara "Arcispedale Sant'Anna"; 🇮🇹 Cona, Italy

Ospedale San Salvatore; 🇮🇹 Coppito, Italy

Ospedale Santa Maria Nuova; 🇮🇹 Firenze, Italy

AOU Careggi - Site 08067; 🇮🇹 Firenze, Italy

AOU Careggi - Site 08081; 🇮🇹 Firenze, Italy

AOU Careggi - Site 08090; 🇮🇹 Firenze, Italy

Azienda Ospedaliera Universitaria "Ospedali Riuniti" di Foggia; 🇮🇹 Foggia, Italy

Ospedale Policlinico San Martino; 🇮🇹 Genova, Italy

Presidio Ospedaliero S.O. Padre Antero Micone; 🇮🇹 Genova, Italy

Ospedale della Misericordia; 🇮🇹 Grosseto, Italy

Ospedale Sant'Andrea; 🇮🇹 La Spezia, Italy

ASP Catanzaro Presidio Ospedaliero "Giovanni Paolo II"; 🇮🇹 Lamezia Terme, Italy

Ospedale Vito Fazzi; 🇮🇹 Lecce, Italy

Ospedale Mater Salutis; 🇮🇹 Legnago, Italy

Presidio Ospedaliero "Madonna delle Grazie"; 🇮🇹 Matera, Italy

Presidio ospedaliero San Giovanni di Dio; 🇮🇹 Melfi, Italy

A.O.U. Policlinico "G. Martino"; 🇮🇹 Messina, Italy

ULSS 3 SERENISSIMA Ospedale dell'Angelo; 🇮🇹 Mestre, Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Site 08039; 🇮🇹 Milano, Italy

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Site 08097; 🇮🇹 Milano, Italy

Ospedale San Luca - Gruppo Istituto Auxologico Italiano; 🇮🇹 Milano, Italy

IRCCS Ospedale Galeazzi-Sant'Ambrogio; 🇮🇹 Milano, Italy

ASST Grande Ospedale Metropolitano Niguarda; 🇮🇹 Milano, Italy

Ospedale Niguarda; 🇮🇹 Milano, Italy

ULSS 3 Serenissima Presidio Ospedaliero di Mirano; 🇮🇹 Mirano, Italy

AOU Modena Policlinico Modena; 🇮🇹 Modena, Italy

A.O.R.N. Antonio Cardarelli; 🇮🇹 Napoli, Italy

A.O.R.N. MONALDI OSPEDALE DEI COLLI Ospedale Monaldi; 🇮🇹 Napoli, Italy

A.O.U. Federico Ii; 🇮🇹 Napoli, Italy

Azienda Ospedaliera Specialistica dei Colli Ospedale Monaldi; 🇮🇹 Napoli, Italy

Policlinico Università Federico II - Napoli; 🇮🇹 Napoli, Italy

Ospedale Umberto I; 🇮🇹 Nocera Inferiore, Italy

AOU Maggiore della Carità di Novara; 🇮🇹 Novara, Italy

Ospedale San Giacomo; 🇮🇹 Novi Ligure, Italy

Azienda ospedaliera-Università di Padova; 🇮🇹 Padova, Italy

A.O.U. Policlinico "P. Giaccone"; 🇮🇹 Palermo, Italy

Casa di Cura Triolo Zancla Hospital; 🇮🇹 Palermo, Italy

ICS Maugeri; 🇮🇹 Pavia, Italy

USL Umbria I; 🇮🇹 Perugia, Italy

Azienda Ospedaliera S. Maria della Misericordia di Perugia; 🇮🇹 Perugia, Italy

Ospedale Guglielmo da Saliceto; 🇮🇹 Piacenza, Italy

Fondazione Monasterio; 🇮🇹 Pisa, Italy

P. O. Portogruaro; 🇮🇹 Portogruaro, Italy

Azienda Ospedaliera Regionale San Carlo di Potenza; 🇮🇹 Potenza, Italy

Nuovo Ospedale Santo Stefano; 🇮🇹 Prato, Italy

Azienda Sanitaria Provinciale di Ragusa Ospedale Giovanni Paolo II; 🇮🇹 Ragusa, Italy

Ospedale Santa Maria delle Croci; 🇮🇹 Ravenna, Italy

ASST Rhodense - Ospedale di Circolo di Rho; 🇮🇹 Rho, Italy

Ospedale San Camillo De Lellis; 🇮🇹 Rieti, Italy

Ospedale Infermi AUSL Romagna; 🇮🇹 Rimini, Italy

Ospedale degli Infermi di Rivoli; 🇮🇹 Rivoli, Italy

Policlinico Tor Vergata; 🇮🇹 Roma, Italy

Ospedale Sandro Pertini; 🇮🇹 Roma, Italy

Policlinico Umberto I; 🇮🇹 Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Site 08046; 🇮🇹 Roma, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Site 08121; 🇮🇹 Roma, Italy

Policlinico Casilino; 🇮🇹 Roma, Italy

AOU S. Andrea; 🇮🇹 Roma, Italy

A.O. San Giovanni di Dio e Ruggi D'Aragona; 🇮🇹 Salerno, Italy

ASST Valle Olona P.O. Saronno; 🇮🇹 Saronno, Italy

Ospedale S. Bartolomeo; 🇮🇹 Sarzana, Italy

AOU Sassari Ospedale SS. Annunziata; 🇮🇹 Sassari, Italy

IRCCS Multimedica; 🇮🇹 Sesto San Giovanni, Italy

A.O.U. Senese Ospedale Santa Maria alle Scotte; 🇮🇹 Siena, Italy

AOU Senese- Policlinico Le Scotte; 🇮🇹 Siena, Italy

Casa di cura Villa Verde; 🇮🇹 Taranto, Italy

Azienda Ospedaliera Santa Maria; 🇮🇹 Terni, Italy

Ospedale Mauriziano Presidio Umberto I; 🇮🇹 Torino, Italy

AOU Ospedali Riuniti di Ancona; 🇮🇹 Torrette, Italy

Ospedale Santa Chiara; 🇮🇹 Trento, Italy

ULLS 2 MARCA TREVIGIANA Ospedale Ca' Foncello; 🇮🇹 Treviso, Italy

Ospedale di Cattinara; 🇮🇹 Trieste, Italy

Ospedale Santa Maria della Misericordia; 🇮🇹 Urbino, Italy

ASST Settelaghi Ospedale di Circolo e Fondazione Macchi; 🇮🇹 Varese, Italy

Ospedale Castelli Verbania; 🇮🇹 Verbania, Italy

ZGT; 🇳🇱 Almelo, Netherlands

Meander Mc; 🇳🇱 Amersfoort, Netherlands

AUMC; 🇳🇱 Amsterdam, Netherlands

Mc Leeuwarden; 🇳🇱 Amsterdam, Netherlands

Rijnstate; 🇳🇱 Arnhem, Netherlands

AMPHIA; 🇳🇱 Breda, Netherlands

Albert Schweitzer; 🇳🇱 Dordrecht, Netherlands

ZGV; 🇳🇱 Ede, Netherlands

Maxima Medisch Centrum; 🇳🇱 Eindhoven, Netherlands

GHZ; 🇳🇱 Gouda, Netherlands

Spaarne Gasthuis; 🇳🇱 Haarlem, Netherlands

Saxenburgh Medisch Centrum; 🇳🇱 Hardenberg, Netherlands

Tergooi Mc; 🇳🇱 Hilversum, Netherlands

Treant Bethesda Hoogeveen; 🇳🇱 Hoogeveen, Netherlands

Dijklander; 🇳🇱 Hoorn, Netherlands

BOVEN IJ; 🇳🇱 Leeuwarden, Netherlands

ALRIJNE; 🇳🇱 Leiderdorp, Netherlands

MUMC+; 🇳🇱 Maastricht, Netherlands

Erasmus Mc; 🇳🇱 Rotterdam, Netherlands

MAASSTAD; 🇳🇱 Rotterdam, Netherlands

SKB; 🇳🇱 Tiel, Netherlands

ZRT; 🇳🇱 Winterswijk, Netherlands

Isala Zwolle; 🇳🇱 Zwolle, Netherlands

Hospital Abente y Lago; 🇪🇸 A Coruña, Spain

Hospital General de Albacete; 🇪🇸 Albacete, Spain

Hospital Virgen de los Lirios; 🇪🇸 Alcoi, Spain

Hospital Universitario Fundación Alcorcón; 🇪🇸 Alcorcón, Spain

Hospital General Universitario Dr. Balmis; 🇪🇸 Alicante, Spain

Hospital Universitario Torrecárdenas; 🇪🇸 Almeria, Spain

Hospital Universitario Central de Asturias; 🇪🇸 Asturias, Spain

Clínica Mapfre Salud Gijón; 🇪🇸 Asturias, Spain

Hospital Universitario San Agustin; 🇪🇸 Asturias, Spain

Hospital Vital Álvarez-Buylla; 🇪🇸 Asturias, Spain

Hospital Universitario Nuestra Señora del Perpetuo Socorro; 🇪🇸 Badajoz, Spain

Hospital Germans Trias i Pujol; 🇪🇸 Badalona, Barcelona, Spain

Hospital Universitario de Cruces; 🇪🇸 Barakaldo, Spain

Hospital del Mar; 🇪🇸 Barcelona, Spain

Hospital de Sant Pau; 🇪🇸 Barcelona, Spain

Hospital Clínic de Barcelona; 🇪🇸 Barcelona, Spain

Hospital Clínico de Barcelona; 🇪🇸 Barcelona, Spain

Hospital de Bellvitge; 🇪🇸 Barcelona, Spain

Hospital Universitario de Basurto; 🇪🇸 Bilbao, Spain

Hospital Universitario de Burgos; 🇪🇸 Burgos, Spain

Hospital General Universitario de Castellón; 🇪🇸 Castellón de la Plana, Spain

Hospital Universitario Reina Sofía; 🇪🇸 Cordoba, Spain

Hospital del Henares; 🇪🇸 Coslada, Madrid, Spain

Hospital Universitario San Pedro de Alcántara; 🇪🇸 Cáceres, Spain

Hospital Universitario Puerta del Mar; 🇪🇸 Cádiz, Spain

Hospital de Denia; 🇪🇸 Denia, Spain

Hospital UNiversitario de Donostia; 🇪🇸 Donostia, Spain

Hospital de Fuenlabrada; 🇪🇸 Fuenlabrada Madrid, Spain

Hospital Universitario de Cabueñes; 🇪🇸 Gijon, Spain

Hospital Universitario Virgen de las Nieves; 🇪🇸 Granada, Spain

Hospital Universitario San Cecilio; 🇪🇸 Granada, Spain

Hospital Universitario Juan Ramón Jiménez; 🇪🇸 Huelva, Spain

Hospital Universitario Médico-Quirúrgico de Jaén; 🇪🇸 Jaén, Spain

Hospital Universitari de Bellvitge; 🇪🇸 L'Hospitalet de Llobregat, Spain

Hospital San Rafael; 🇪🇸 La Coruña, Spain

Hospital Universitario de Gran Canaria Dr. Negrín; 🇪🇸 Las Palmas de Gran Canaria, Spain

Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria; 🇪🇸 Las Palmas de Gran Canaria, Spain

Hospital Universitario de León; 🇪🇸 León, Spain

HOSPITAL UNIVERSITARi ARNAU DE VILANOVA; 🇪🇸 Lleida, Spain

Hospital San Pedro; 🇪🇸 Logroño, Spain

Hospital Universitario Lucus Augusti; 🇪🇸 Lugo, Spain

Hospital UNiversitario la Princesa; 🇪🇸 Madrid, Spain

Hospital Universitario Gregorio Marañón; 🇪🇸 Madrid, Spain

Hospital Ruber Internacional; 🇪🇸 Madrid, Spain

Hospital Universitario Ramón y Cajal; 🇪🇸 Madrid, Spain

Hospital Clínico San Carlos; 🇪🇸 Madrid, Spain

Hospital Clínico Universitario San Carlos; 🇪🇸 Madrid, Spain

Hospital Universitario Fundación Jiménez Díaz; 🇪🇸 Madrid, Spain

Hospital Universitario 12 de Octubre; 🇪🇸 Madrid, Spain

Hospital Universitario La Paz; 🇪🇸 Madrid, Spain

Hospital Central de la Defensa Gómez-Ulla; 🇪🇸 Madrid, Spain

Hospital HM Montepríncipe; 🇪🇸 Madrid, Spain

Hospital Universitario de Torrejón; 🇪🇸 Madrid, Spain

Hospital Universitario Puerta de Hierro Majadahonda; 🇪🇸 Majdahonda Madrid, Spain

Consulta de Cardiología Dr. Javier Mora Robles; 🇪🇸 Malaga, Spain

Hospital Costa del Sol; 🇪🇸 Marbella Málaga, Spain

Hospital de Mendaro; 🇪🇸 Mendaro, Spain

Hospital General Universitario Reina Sofía; 🇪🇸 Murcia, Spain

Hospital Clínico Universitario Virgen Arrixaca; 🇪🇸 Murcia, Spain

Hospital Regional Universitario de Málaga; 🇪🇸 Málaga, Spain

Hospital Universitario Virgen de la Victoria; 🇪🇸 Málaga, Spain

Hospital Universitario Son LLatzer; 🇪🇸 Palma de Mallorca, Spain

Hospital Universitario de Navarra; 🇪🇸 Pamplona, Spain

Hospital de Sagunto; 🇪🇸 Port De Sagunt, Spain

Hospital Universitario de Salamanca; 🇪🇸 Salamanca, Spain

Hospital Santa Caterina; 🇪🇸 Salt, Girona, Spain

Complexe hospitalari Moisès Broggi; 🇪🇸 Sant Joan Despi, Barcelona, Spain

Hospital Universitario Marqués de Valdecilla; 🇪🇸 Santander, Spain

Hospital Clinico Universitario Santiago de Compostela; 🇪🇸 Santiago de Compostela, Spain

Hospital Universitario Virgen del Rocio; 🇪🇸 Sevilla, Spain

Hospital de Valme; 🇪🇸 Sevilla, Spain

Hospital Universitario Vírgen del Rocío; 🇪🇸 Sevilla, Spain

Complejo Asistencial Universitario de Soria; 🇪🇸 Soria, Spain

Hospital de Sant Pau i Santa Tecla; 🇪🇸 Tarragona, Spain

Hospital Universitari de Tarragona Joan XXIII; 🇪🇸 Tarragona, Spain

Hospital Universitario Mútua de Terrassa; 🇪🇸 Terrassa Barcelona, Spain

Hospital General Universitario de Toledo; 🇪🇸 Toledo, Spain

Hospital Clínico Universitario de Valencia; 🇪🇸 Valencia, Spain

Hospital Arnau de Vilanova; 🇪🇸 Valencia, Spain

Vithas Valencia 9 de Octubre; 🇪🇸 Valencia, Spain

Consorcio Hospital General Universitario de Valencia; 🇪🇸 Valencia, Spain

Hospital Universitari i Politècnic La Fe; 🇪🇸 Valencia, Spain

Hospital Universitario Rio Hortega; 🇪🇸 Valladolid, Spain

Hospital Álvaro Cunqueiro; 🇪🇸 Vigo Pontevedra, Spain

Hospital Clinico Universitaro Lozano Blesa; 🇪🇸 Zaragoza, Spain

Diabetologie & Endokrinologie Baden; 🇨🇭 Baden, Switzerland

University Hospital Basel; 🇨🇭 Basel, Switzerland

Inselspital, Universitätsspital Bern; 🇨🇭 Bern, Switzerland

Praxis Dr. med Urs Beat Gröflin; 🇨🇭 Binningen, Switzerland

Hochgebirgsklinik Davos; 🇨🇭 Davos, Switzerland

Schlossberg Ärztezentrum Frauenfeld; 🇨🇭 Frauenfeld, Switzerland

Hôpitaux Universitaires de Genève; 🇨🇭 Genève, Switzerland

Spital Lachen AG; 🇨🇭 Lachen, Switzerland

Centre Hospitalier Universitaire Vaudois (CHUV); 🇨🇭 Lausanne, Switzerland

University of Lausanne; 🇨🇭 Lausanne, Switzerland

Kantonsspital Baselland; 🇨🇭 Liestal, Switzerland

EOC Ente Ospedaliero Cantonale; 🇨🇭 Lugano, Switzerland

MIP Associazione Medico in Pratica c/o Studio Medico Cardiologico Acquistapace; 🇨🇭 Lugano, Switzerland

Praxis Prof. Dr. med. Gottfried Rudofsky; 🇨🇭 Olten, Switzerland

HÔPITAL RIVIERA-CHABLAIS, VAUD-VALAIS, Centre hospitalier de Rennaz; 🇨🇭 Rennaz, Switzerland

Kantonsspital St.Gallen; 🇨🇭 St.Gallen, Switzerland

Spital Thun; 🇨🇭 Thun, Switzerland

Prof. Dr. med. Stephane Bosquet; 🇨🇭 Yverdon-les-Bains, Switzerland

Diagnostisches und Therapeutisches Herzzentrum; 🇨🇭 Zürich, Switzerland

Universitätsspital Zürich; 🇨🇭 Zürich, Switzerland

Royal United Hospitals Bath NHS Foundation Trust; 🇬🇧 Bath, United Kingdom

South Eastern Ulster Hospital; 🇬🇧 Belfast, United Kingdom

University Hospital of Wales; 🇬🇧 Cardiff, United Kingdom

Rowden Surgery; 🇬🇧 Chippenham, United Kingdom

Craigavon Area Hospital; 🇬🇧 Craigavon, United Kingdom

Darlington Memorial Hospital; 🇬🇧 Darlington, United Kingdom

Carmel Medical Practice; 🇬🇧 Darlington, United Kingdom

Dartford and Gravesham NHS Trust Darent Valley Hospital; 🇬🇧 Dartford, United Kingdom

University Hospital North Durham; 🇬🇧 Durham, United Kingdom

Southend University Hospital; 🇬🇧 Essex, United Kingdom

Oaks Healthcare; 🇬🇧 Hampshire, United Kingdom

West Morland General Hospital; 🇬🇧 Kendal, United Kingdom

North Blaby PCN; 🇬🇧 Leicester, United Kingdom

Lincoln County Hospital; 🇬🇧 Lincoln, United Kingdom

Barts Health NHS Trust/ QMUL; 🇬🇧 London, United Kingdom

Freuchen Medical Centre; 🇬🇧 London, United Kingdom

Royal Free Hospital Lipid Clinic; 🇬🇧 London, United Kingdom

Hammersmith Hospital; 🇬🇧 London, United Kingdom

Imperial College London; 🇬🇧 London, United Kingdom

Manchester Royal Infirmary; 🇬🇧 Manchester, United Kingdom

Manchester University NHS Foundation Trust; 🇬🇧 Manchester, United Kingdom

Wythenshawe Hospital; 🇬🇧 Manchester, United Kingdom

STRIVE, The James Cook University Hospital; 🇬🇧 Middlesbrough, United Kingdom

North Tees Hospital; 🇬🇧 Northumbria, United Kingdom

City Hospital; 🇬🇧 Nottingham, United Kingdom

Derriford Hospital Lipid Clinic; 🇬🇧 Plymouth, United Kingdom

Queen Alexandra Hospital; 🇬🇧 Portsmouth, United Kingdom

Whiston Hospital; 🇬🇧 Prescot, United Kingdom

North Manchester General Hospital; 🇬🇧 Salford, United Kingdom

Moorgreen Hospital; 🇬🇧 Southampton, United Kingdom

Queen's Hospital Lipid Clinic; 🇬🇧 Staffordshire, United Kingdom

Princess Royal Hospital; 🇬🇧 Telford, United Kingdom

Torbay and South Devon NHS Foundation Trust; 🇬🇧 Torquay, United Kingdom

Trowbridge Health Centre; 🇬🇧 Trowbridge, United Kingdom

Royal Cornwall Hospital; 🇬🇧 Truro, United Kingdom

North Wales Cardiac Centre; 🇬🇧 Wales, United Kingdom

Wansford and Kings Cliffe Practice; 🇬🇧 Wansford, United Kingdom

Bridgewater Surgeries; 🇬🇧 Watford, United Kingdom

Sheepcot Medical Centre; 🇬🇧 Watford, United Kingdom