Effect of Red Meat Intake on Occurrence of Serum Non-transferrin Bound Iron (NTBI)

Not Applicable

• Conditions: Healthy
• Interventions: Other: Beef

• Registration Number: NCT03019393
• Lead Sponsor: Thomas Walczyk

Brief Summary

This study aims to evaluate the effect of red meat intake on occurrence of non-transferrin bound iron (NTBI)

Detailed Description

During Visit 1, blood samples will be collected to assess iron status. During Visit 2, after an overnight fast, participant will be given a standardized meal (rice and potatoes) with a portion of cooked beef (200 g). Blood samples will be collected right before and 2 hour after the meal for NTBI analysis.

NTBI concentration before and after meal consumption will be compared.

Study Timeline

• Study Start: 2016-05
• Status Verified: 2017-01
• Study First Submitted: 2017-01-10
• Study First Submitted QC: 2017-01-11
• Last Update Submitted: 2017-01-11
• Study First Posted: 2017-01-12
• Last Update Posted: 2017-01-12
• Primary Completion: 2017-03
• Study Completion: 2017-03

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• Apparently healthy male volunteers (21 - 45 years old)
• C-reactive protein (CRP) < 5 mg/L

Exclusion Criteria

• Blood donation or significant blood loss (e.g. surgery) within the past 4 months
• Regular intake of iron and other nutrient supplements within the past 4 months
• Regular intake of medication except oral contraceptives
• Acute or recent inflammatory or infectious symptoms
• Chronic gastrointestinal disorders or metabolic diseases
• Smoking
• Coeliac disease or gluten-related disorders
• Iron deficiency anemia (Hb < 14 g/dL for males) with serum ferritin concentration < 30 ng/mL)
• Non-iron deficiency anemia (serum ferritin concentration within normal range (30 - 300 ng/mL for males) but low hemoglobin (< 14 g/dL for males)
• Iron overload conditions (serum ferritin concentration > 300 ng/mL for males)
• Known hereditary disorders of iron metabolism

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Beef	Beef	Beef topside fully cooked, 200g

Primary Outcome Measures

Name	Time	Method
Occurrence of serum non-transferrin bound iron (NTBI) after consumption of red meat	2 hour post meal administration	Blood samples collected 2 h after consumption of red meat will be analyzed for non-transferrin bound iron (NTBI) concentration

Trial Locations

Locations (1)

National University of Singapore; National University Hospital; 🇸🇬 Singapore, Singapore