The effect of perioperative ketamine on the risk of development of chronic post-surgical pain in patients undergoing elective or expedited surgery and anaesthesia for major orthopaedic, abdominal or non cardiac thoracic surgery.

The University of Melbourne0 个研究点目标入组 4,884 人开始时间: 2017年12月11日最近更新: 2023年10月30日

试验速览

暂无简介。

•Patients with ASA 1-3 undergoing elective or expedited surgery and anaesthesia for abdominal surgery involving an expected skin incision at least 8cm in length and including open herniorraphy; non-cardiac thoracic surgery, including mastectomy and breast reconstruction surgery, and including all video-assisted thoracoscopic surgery; hip, knee and shoulder joint arthroplasty and spinal surgery involving an expected skin incision at least 8cm; plan for postoperative opioid analgesia; planned hospital stay of at least one night post-operatively; expected to be alive at 12 months post index surgery.

•Patients unable to provide written informed consent
•Patients who are pregnant or lactating
•Body mass index (BMI) over 40 kg/m2 and weight over 130kg
•ASA physical status 4 or 5
•Planned use of intra or postoperative continuous intravenous lignocaine infusion
•Uncontrolled hypertension (SBP >180mmHg) on admission
•Poorly controlled atrial fibrillation (ventricular response rate >120/min) on admission
•Uncontrolled heart failure
•Intracranial surgery or raised intracranial pressure
•History of haemorrhagic stroke
•Severe impairment of liver function
•Previous adverse reaction to ketamine
•Documented complex regional pain syndrome
•History of epilepsy or convulsions
•History of psychosis, or of illicit drug use or known illegal activities
•Previously randomised to the ROCKet trial

发起方