Mesenchymal Stem Cells Treatment for AIDS Patients at Late Stage
- Registration Number
- NCT05939167
- Lead Sponsor
- Cell Energy Life Sciences Group Co. LTD
- Brief Summary
The goal of this study is to conduct a prospective, double-blind, randomized placebo-controlled clinical trial to investigate the safety and efficacy of mesenchymal stem cells treatment for AIDS patients at late stage.
- Detailed Description
Mesenchymal stem cells (MSCs) possess immunomodulatory, anti-inflammatory, and regenerative properties. The safety and effectiveness of MSCs have been investigated in various clinical trials for the treatment of several disorders, including graft-versushost disease, inflammatory bowel disease, and multiple sclerosis. It has been reported that MSC treatment in HIV-infected patients with immunological nonresponders resulted in a significant increase in circulating CD4+ T lymphocytes and a decrease of the activation of T lymphocytes and soluble inflammation mediator levels without significant adverse effects or loss of viremia control. However, the therapeutic efficacy of MSC treatment for AIDS patients at late stage is not well-understood. This study aims to investigate the safety and efficacy of MSC treatment for AIDS patients at late stage.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
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Confirmed HIV infection, aged 18-65, both genders
-
CD4+T count less than 350 cells/ul at baseline.
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No serious AIDS related events. 3. could understand and sign the informed consent form and comply with the requirements of this study.
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agree not to participate in other studies and not to receive other immunotherapies during the period of participation in this study
- have HBV/HCV/HDV/HEV infection, and the virological test is positive.
- The viral load for CMV and EBV is more than 1000 copies/ML.
- have HIV-2 infection.
- have serious complications in organs including renal, circulatory, respiratory, digestive, endocrine, neural and immunological diseases and tumors.
- received treatment of hormones or other immunosuppressive drugs for a long time.
- with serious AIDS related or unrelated events.
- received immunosuppressive drugs or systemic cytotoxic drugs for more than 3 months before recruiting
- have poor compliance during treatment.
- drug addiction within 6 months, or the urine drug test is positive
- participate in other clinical trials currently
- pregnant, breastfeeding, or have fertility requirements.
- unable or unwilling to provide informed consents, or unable to comply with research requirements.
- Other serious situations that may hinder clinical trials.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description mesenchymal stem cells standard treatment mesenchymal stem cell transplant mesenchymal stem cells for 3 times placebo control saline use saline mesenchymal stem cells enhanced treatment mesenchymal stem cell transplant mesenchymal stem cells for 6 times
- Primary Outcome Measures
Name Time Method CD4+ T cell counts after MSCs transfusion 48 weeks at week 12, 24 and 48, evaluate CD4+ T cell counts and compare with baseline
Number of participants with side effects in MSCs treatment groups 48 weeks Investiagte the number of participants with treatment-related adverse events as assessed by CTCAE v4.0 after MSCs infusion.
- Secondary Outcome Measures
Name Time Method HIV RNA viral load 48 weeks At week 12, 24 and 48, test HIV RNA viral load in participants' blood using RT-PCR and compare with baseline.
Trial Locations
- Locations (4)
Beijing 302 Hospital
🇨🇳Beijing, China
Shenzhen Third People's Hospital
🇨🇳Shenzhen, China
Beijing YouAn Hospital
🇨🇳Beijing, China
The Fifth Hospital of Shijiazhuang
🇨🇳Shijiazhuang, China