Magnetic Resonance imaging-guided high intensity focused ultrasound for patients with Desmoid-type fibromatosis

MC Utrecht0 个研究点目标入组 13 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•Patients > 18 years
•-Histological evidence of DTF
•-Patients with failure of active surveillance* for their present manifestation of DTF
•-Desmoid tumor must be targetable with MR-HIFU device
•-Desmoid tumor must be visible on pre-treatment MR-imaging
•-Patient is able to fit in the MRI gantry
•-Capable to understand and sign informed consent
•*failure of active surveillance due to tumor growth and/or new or worsening symptoms

•-Personal or family history of familial adenomatous polyposis (FAP)
•-Intra-abdominal tumor localization
•-Patients with a tumor greater than 10 centimeters
•-Patients who have undergone prior active treatment (systemic therapy, radiotherapy, prior ablation) for the present manifestation of DTF
•-Patients with recurrent disease within 12 months after treatment for their prior desmoid tumor
•-Patients weighing more than 140 kilograms
•-Pregnancy
•-Contra indications to MRI, MRI contrast agents or sedation
•-Unavoidable critical structures or dense tissues in target area*
•-Any other condition, which in the opinion of the investigators, would put the patient at increased risk or otherwise make the patients unsuitable for this study
•*as judged by the operator. e.g.: nerve bundles, skin, extensive scarring, non-targeted bones, air (e.g. hollow viscera), (external) fixation device, surgical clips

发起方

MC Utrecht