Magnetic Resonance imaging-guided high intensity focused ultrasound for patients with Desmoid-type fibromatosis

MC Utrecht0 sites13 target enrollmentTBD

Overview

No summary available.

Registry

who.int

Start Date

TBD

End Date

TBD

Last Updated

2 years ago

Study Type

Interventional

Sponsor

MC Utrecht

•Patients \> 18 years
•\-Histological evidence of DTF
•\-Patients with failure of active surveillance\* for their present manifestation of DTF
•\-Desmoid tumor must be targetable with MR\-HIFU device
•\-Desmoid tumor must be visible on pre\-treatment MR\-imaging
•\-Patient is able to fit in the MRI gantry
•\-Capable to understand and sign informed consent
•\*failure of active surveillance due to tumor growth and/or new or worsening symptoms

•\-Personal or family history of familial adenomatous polyposis (FAP)
•\-Intra\-abdominal tumor localization
•\-Patients with a tumor greater than 10 centimeters
•\-Patients who have undergone prior active treatment (systemic therapy, radiotherapy, prior ablation) for the present manifestation of DTF
•\-Patients with recurrent disease within 12 months after treatment for their prior desmoid tumor
•\-Patients weighing more than 140 kilograms
•\-Pregnancy
•\-Contra indications to MRI, MRI contrast agents or sedation
•\-Unavoidable critical structures or dense tissues in target area\*
•\-Any other condition, which in the opinion of the investigators, would put the patient at increased risk or otherwise make the patients unsuitable for this study