Early statin treatment in patients with acute coronary syndrome: The best intensive LDL-cholesterol lowering therapy is sought by two different regimens during half a year treatment using Volumetric Intravascular Ultrasound Analysis (ESTABLISH-2 study)

Not Applicable

• Conditions: To asses the efficacy of two different regimens of intensive LDL-cholesterol lowering therapy with statin or statin and ezetimibe on the plaque volume and plaque morphology in patients with acute coronary syndrome during 6 months.

• Registration Number: JPRN-UMIN000006593
• Lead Sponsor: Juntendo University School of Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-11-01
• Study Completion: 2012-06-01
• Last Update Posted: 17 October 2023

Recruitment & Eligibility

• Status: Complete: follow-up continuing
• Sex: All
• Target Recruitment: 126

Inclusion Criteria

Not provided

Exclusion Criteria

A case of failed PCI diseased bypass graft recommended CABG cardiogenic shock A case of administration of other lipid-lowering drugs (clofibrate, probucol, nicotinic acid, or other prohibited drug without ezetimibe).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The percent change in plaque and vessel volume in non-culprit lesion on IVUS analysis during 6 months after onset of ACS.

Secondary Outcome Measures

Name	Time	Method
Correlation between the percent change in plaque volume and the biomarkers including LDL-cholesterol level. Major adverse cardiovascular event