Early statin treatment against progressing stroke. A Randomised pilot study
Phase 3
- Conditions
- acute ischemic stroke
- Registration Number
- JPRN-UMIN000006296
- Lead Sponsor
- Department of Neurology, St. Marianna University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
Not provided
Exclusion Criteria
Exclusion criteria 1. statin treatment within 3 months 2. chronic devastating illness 3. stroke caused by arterial dissection, or moyamoya disease 4. acute ischemic heart disease, severe inflammatory disease, autoimmune disease, collagen disease or malignancy requiring treatment 5. pregnancy or possibility of pregnancy 6. recurrent cerebral infarction that had developed 6 months after the previous episode 7. disability with modified Rankin scale (mRS) score ≥2 before onset 8.steroid or NSAID treatment
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Progression in stroke deficits within 14 days(NIHSS>4) 2. Changes in proinfalmmatory biomarkers; hsCRP, IL-6, IL-10, IL-18, MMP-2, MMP-9, TNF-alpha at Day-1,Day-3, Day-7, Day14.
- Secondary Outcome Measures
Name Time Method 1. infarct volume 2. mRS<2 at 90 days