Detecting SARS-CoV-2 Virus in Tears From Patients With COVID-19
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 7
- 试验地点
- 1
- 主要终点
- COVID-19 Virus Detection in Tears
研究概览
简要总结
Purpose:
- To determine the presence of SARS-CoV-2 in tears
- To determine SARS-CoV-2 receptors in tear production system
详细描述
This is a prospective case series. NP swab and tear samples will be collected simultaneously from the confirmed or suspected COVID-19 patients. The samples will be transferred to the lab for SARS-CoV-2 testing. The presence of absence of SARS-CoV-2 will be compared in tears versus NP swabs.
The second part of the study is a histopathology examination series. Normal lacrimal gland and ocular surface tissue samples already stored at the UMN ocular pathology lab and Lion's Gift of Sight Eye Bank will be used for IHC staining for ACE2 and similar targets.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients presenting at study sites with confirmed or suspected COVID-19
排除标准
- •Pregnancy or nursing
- •non-English speakers
- •Those unable to read
- •Those in other vulnerable study populations
结局指标
主要结局
COVID-19 Virus Detection in Tears
时间窗: At day 1 of study participation
Outcome is reported as the percent of tear samples that test either "positive", "negative", or "indeterminant" for SARS-CoV-2 Virus presence.
COVID-19 Virus Detection in Nasopharyngeal Swabs
时间窗: At day 1 of study participation
Outcome is reported as the percent of nasopharyngeal swab samples that test either "positive", "negative", or "indeterminant" for SARS-CoV-2 Virus presence.
次要结局
- Expression of ACE2 in Ocular Surface Samples(At day 1 of study participation)
- Expression of ACE2 in Lacrimal Gland Samples(At day 1 of study participation)