COVID-19 in Patients With Anosmia in Egypt

Completed

• Conditions: Anosmia; Covid19; Dysgeusia

• Registration Number: NCT04473157
• Lead Sponsor: Ain Shams University

Brief Summary

The study aims to test the frequency of severe acute respiratory syndrome new corona virus SARS-CoV-2 or other respiratory viruses in patients presenting with anosmia or dysgeusia to Ain Shams University Hospitals, Cairo, Egypt.

Detailed Description

Fifty Patients presenting to Triage and/or Ear, Nose and Throat (ENT) clinics in Ain Shams University Hospitals with the chief complaint of Anosmia/ dysgeusia in the period July- September 2020; will undergo thorough history taking, clinical assessment and polymers chain reaction rt-PCR to SARS-COV2; and if proven negative to COVID 19, PCR to other respiratory pathogens will be tested. COVID-19 patients will be managed according to the standard protocol of Ain Shams University Hospitals. Follow up after 3 weeks for the outcome of recovery of the smell sense and seroconversion by rapid test for immunoglobulins IgM/ IgG of COVID 19, for the probability of a false negative PCR at initial visit.

Ethical committee approval for the current study protocol was obtained. Patients will be invited to participate and the informed consent will be signed.

Study Timeline

• Study Start: 2020-07-01
• Study First Submitted: 2020-07-15
• Study First Submitted QC: 2020-07-15
• Study First Posted: 2020-07-16
• Primary Completion: 2020-11-30
• Study Completion: 2020-12-30
• Status Verified: 2021-01
• Last Update Submitted: 2021-01-14
• Last Update Posted: 2021-01-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 58

Inclusion Criteria

• adult (>18 years) patients presented with acute-onset anosmia.

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Exclusion Criteria

• patients with anosmia or gustatory dysfunctions before the epidemic; patients with previous history of chronic sinusitis or previous sinus surgery.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Recovery from Anosmia	3 weeks	subjective questionnaire about smell and taste
Seroconversion	3 weeks	developing IgM/ IgG antibodies by rapid test

Secondary Outcome Measures

Name	Time	Method
COVID 19	3 weeks	developing other symptoms of COVID 19

Trial Locations

Locations (1)

Ain Shams University; 🇪🇬 Cairo, Egypt