ew approaches in genetic analysis to predict for CRC risk.

Not Applicable

Completed

• Conditions: Bowel Cancer; Cancer - Bowel - Anal; Cancer - Bowel - Back passage (rectum) or large bowel (colon); Cancer - Bowel - Small bowel (duodenum and ileum

• Registration Number: ACTRN12605000259640
• Lead Sponsor: CSIRO, Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-02
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

Cancer patients:1: Patients from families with 3 or more first-degree relatives having CRC, with one diagnosed less than 50 years of age. 2: Patients from families with 2 or more first-degree relatives having CRC. 3: Patients from families with one first degree and one or more second-degree relatives having CRC.Unaffected Individuals:1: First-degree relatives, over 70 years of age, from the above families who have no history of colorectal neoplasia.2:Younger first-degree relatives, at least 50 years of age, who are colonoscopy negative.

Exclusion Criteria

No exclusion criteria

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To identify molecular markers of potential value in understanding predisposition to CRC by their association with gene variants that increase the risk of CRC.<br>The study will be a family based analysis of SNP genotypes for cases and controls within families and between families. Transmission of disease associated SNPs will be assessed to determine within-family association and linkage and then to calculate across-family associations.[2-3 blood samples per week over 36 months approx]

Secondary Outcome Measures

Name	Time	Method
If linkage is found then comparisons between families will be undertaken to determine whether the same SNP allele (or alleles) is associated in other families, thus providing a direct indicator of CRC risk. If this is the case, further testing in different ethnic groups may be necessary to extend the findings more broadly[Nil]