The Efficacy of Oral Melatonin Attenuating Renal Ischaemia-Reperfusion Injury in Abdominal Aortic Aneurysm Surgery: A Randomized Controlled Trial
Phase 2
- Conditions
- Increased oxidative stress and inflammatory response during abdominal aortic aneurysm repair surgerymelatonin, Abdominal aortic aneurysm, abdominal aortic aneurysm repair, oxidative stress, inflammatory response, Ischemia reperfusion Injury, renal ischemia reperfusion injury, acute kidney injury
- Registration Number
- TCTR20220720006
- Lead Sponsor
- Faculty of Medicine, Chiang Mai University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Enrolling by invitation
- Sex
- All
- Target Recruitment
- 18
Inclusion Criteria
1. All patients above 18 years old
2. Patients are diagnosed abdominal aortic aneurysm and eligibility to elective abdominal aortic aneurysm surgery
Exclusion Criteria
1.The patients with history of regular taking melatonin
2.The patients with known melatonin hypersensitivity or allergy
3.The patients with emergency abdominal aortic aneurysm repair who are not able to take pre-operative oral melatonin
4.The patients who cannot inform consent
5.The patients have absolute NPO
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Acute kidney injury Within 24 hours after surgery KDICO criteria, NGAL level
- Secondary Outcome Measures
Name Time Method