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Clinical Trials/NCT04748029
NCT04748029CompletedNot Applicable

Evaluation of the Prognostic Role of the Systemic Immune Inflammation Index in Postmenopausal Osteoporosis

Ufuk University1 site in 1 country139 target enrollmentStarted: January 1, 2021Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Sponsor
Enrollment
139
Locations
1
Primary Endpoint
Systemic immune inflammation index (SII)

Study Overview

Brief Summary

This study is a retrospective case-control study. In the study, the data of 304 patients who were evaluated in our clinic between January 2017 and January 2020 with a pre-diagnosis or diagnosis of postmenopausal osteoporosis were retrospectively reviewed. Lumbar 1-4 and femoral neck bone mineral densitometry values T scores, ages, sedimentation, C-reactive protein, neutrophil, leukocyte and platelet levels, and mean platelet volume values of the patients were recorded. The neutrophil-lymphocyte ratio was calculated by dividing the neutrophil count by the lymphocyte count, and the platelet-lymphocyte ratio was calculated by dividing the platelet count by the lymphocyte count. The systemic immune inflammation index (SII) was calculated using the formula, SII = platelet count x neutrophil count / lymphocyte count. The aim of this study is to evaluate the prognostic value of the systemic immune inflammation index in postmenopausal osteoporosis and to examine the SII, N / L, PLT / L, MPV, sedimentation (ESR), C reactive protein (CRP), femur and lumbar BMD values and their relationships with each other.

Study Design

Study Type
Observational
Observational Model
Case Control
Time Perspective
Retrospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Having applied to our clinic with the diagnosis or pre-diagnosis of postmenopausal osteoporosis or osteoporosis with pathological fractures

Exclusion Criteria

  • Having a diagnosis of osteoporosis due to conditions other than postmenopausal osteoporosis
  • Those with acute or chronic infection, malignancy and systemic diseases that may change the hematological inflammation parameters to be checked
  • Persons who are missing one or more of the parameters planned to be considered among the obtained data

Outcomes

Primary Outcomes

Systemic immune inflammation index (SII)

Time Frame: 1 month

Systemic immune inflammation index (SII) is a new index related to systemic inflammation calculated by the numbers of lymphocytes, neutrophils and platelets in peripheral blood defined in 2014. The systemic immune inflammation index (SII) is calculated using the formula, SII = platelet count x neutrophil count / lymphocyte count.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor
Ufuk University
Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Elzem Bolkan Günaydın

Lecturer Doctor

Ufuk University

Study Sites (1)

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