The Effect of Frailty and Other Geriatric Syndromes on the Prognosis of Elderly Patients With Acute Coronary Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Death
研究概览
简要总结
This is a prospective observational clinical trail which will recruit 1000-1500 participants over 65 years with frailty and acute coronary syndrome (ACS) in Beijing Friendship hospital. The investigators will conduct frailty assessment (FRAIL scale, CFS, SPPB), comorbidities, functional status (Barthel index, ADL, IADL), nutritional risk (MNA-SF), and then observe the clinical outcomes of elderly ACS participants with frailty. Then, the investigators will follow-up these participants separately in 1,3,6 and 12months, the anticipate follow-up time is 1 year. According to the follow-up results, investigators will evaluate the impact of frailty and other senile syndromes on the short-term and long-term prognosis of ACS, and develop a scoring system for the prognosis evaluation of elderly ACS participants.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Elderly participants over 65
- •Clinical diagnosis of acute coronary syndrome
- •Must be able to follow-up
- •Sign in the informed consent
排除标准
- •Myocardial infarction caused by other acute disease
- •Mental disorders who cannot cooperate to complete the assessment
- •Severe liver dysfunction, kidney disease (CKD 5), end-stage malignant tumor
- •Totally disabled and bedridden
结局指标
主要结局
Death
时间窗: 1 year
All-cause death and cardiac death events
Major Adverse Cardiac and Cerebrovascular events
时间窗: 1 year
Major Adverse Cardiac and Cerebrovascular events including heart failure, cardiac shock, malignant arrhythmia, myocardial infarction, revascularization, and cerebral infarction
次要结局
未报告次要终点
研究者
Sun Ying
Director of department geriatrics, Beijing Friendship Hospital
Beijing Friendship Hospital