Nucleotide Polymorphism in ARDS Outcome: a Whole Exome Sequencing Association Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 105
- 试验地点
- 1
- 主要终点
- Number of survived participants
研究概览
简要总结
Acute respiratory distress syndrome (ARDS) is characterized by increased pulmonary vascular permeability and reduced aerated lung tissue. With an extremely high hospital mortality among 35 - 46%, current therapeutic strategies to increase ARDS survival are still limited. Advances in etiology and pathology of ARDS are urging. Numerous genetic variants were identified associated with ARDS outcome. By whole-exome sequencing association study, our goal was to explore the associations between genetic variants and ARDS outcome.
详细描述
Acute respiratory distress syndrome (ARDS) is characterized by increased pulmonary vascular permeability and reduced aerated lung tissue. With an extremely high hospital mortality among 35 - 46%, current therapeutic strategies to increase ARDS survival are still limited. Advances in etiology and pathology of ARDS are urging. Numerous genetic variants were identified associated with ARDS outcome. Then a few genetic risk factors have been discovered by large-scale genotyping approaches, from in vivo or in vitro models of lung injury, which highlight the importance of identifying genetic biomarkers of ARDS outcome to further improve stratification. The mutational landscape and variability at single nucleotide polymorphisms (SNP) with ARDS outcome in Chinese is unknown, not to mention their associations. By whole-exome sequencing association study, our goal was to explore the associations between genetic variants and ARDS outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult ARDS (according to Berlin definition) patients were enrolled in the trial.
- •The diagnostic criteria included
- •within one week of a known clinical insult or new or worsening respiratory symptoms;
- •chest imaging showing that bilateral opacities-not fully explained by effusions, lobar/lung collapse, or nodules;
- •respiratory failure not fully explained by cardiac failure or fluid overload;
- •arterial partial pressure of oxygen / fraction of inspiration oxygen (PaO2/FiO2 ratio, P/F ratio) less than or equal to 300 mmHg.
- •Exclusion criteria:
- •Patients refused to participate in the study.
排除标准
- 未提供
结局指标
主要结局
Number of survived participants
时间窗: through study completion, an average of 28 day
Survivors and non-survivors in ICU
次要结局
未报告次要终点
研究者
Jingyuan,Xu
Principal Investigator
Southeast University, China