Toxicity of Perirenal Fat in Overweight or Obese Subjects: A Pathophysiological Link Between Uric Acid Stones and Renal Ammonium Formation

Not Applicable

Completed

• Conditions: Uric Acid Stones
• Interventions: Other: acid load test

• Registration Number: NCT02561858
• Lead Sponsor: Centre Hospitalier Universitaire de Nice

Brief Summary

Patients who are overweight or obese, diabetic or not, share with those who are suffering from uric stones the same way to remove abnormal acidity of the body in urine, ie a kidney ammoniogenesis default. This results in an overly acidic urine pH which is directly pathogenic in people predisposed to develop uric stones because the precipitation of urate soluble uric acid is accelerated in acid medium.

Excess visceral fat, particularly perirenal, this defect may promote formation of renal ammonium. Indeed, the perirenal fat is adjacent to the renal cortex and shares with it a common arterial supply via the plexus Turner. Adipokines and fatty acids of the perirenal fat are predisposed to gain the renal cortex, seat of the ammoniogenesis. In humans the pathogenic role of the perirenal fat is demonstrated in chronic kidney disease and essential hypertension. However, the amount of fat and perirenal that of intra-abdominal fat are positively correlated.

Investigators hypothesis is that the perirenal fat also exert a pathogenic role in uric because of anatomical links between kidney stones and greasy environment and because excess fatty acids reaching the renal cortex decreases ammoniogenesis in an animal model metabolic syndrome.

For the test, the investigators will compare the amount of fat and perirenal renal ability to form ammonium in patients with uric or calcium lithiasis taking into account the amount of intra-abdominal fat.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-09-22
• Study First Submitted QC: 2015-09-25
• Study First Posted: 2015-09-28
• Study Start: 2015-10-14
• Primary Completion: 2016-06-24
• Study Completion: 2016-09-29
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-08
• Last Update Posted: 2018-03-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Urolithiasis Uric defined by more than 90% of uric acid anhydrous and / or dihydrate or calcium lithiasis defined by more than 90% mono calcium oxalate and / or dihydrate, and / or carbapatite and / or brushite;
• Overweight and obesity defined by 25 <BMI <35 kg / m2

Exclusion Criteria

• staghorn lithiasis, stones struvite or cystine;
• Primary hyperparathyroidism;
• Hyperthyroidism;
• Any form of calcium or uric lithiasis secondary;
• Abnormal kidney structure (cysts, cortical thinning, kidney tumor);

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
acid load test	acid load test	-

Primary Outcome Measures

Name	Time	Method
the perirenal fat thickness (left)	baseline	This is the perirenal fat thickness measured between the left posterior wall of the kidney and the posterior wall of the abdominal cavity on a TDM section in the plane of the left renal vein.

Secondary Outcome Measures

Name	Time	Method
the perirenal fat thickness (right)	baseline	the average thickness of perirenal fat measured to the right
NH4 + / NAE	at day 7 of a standard diet	It is the ratio NH4 + / NAE measured over 24 hours of urine collected at day 7 of a standard diet; it determines from acid removed as ammonium whose production is regulated physiologically by the kidneys
net acid urinary flow	at day 7 of a standard diet and when urine pH became <5.5	This is the net acid urinary flow and report NH4 + / creat obtained when the urine pH became \<5.5, in an acidic filler.

Trial Locations

Locations (1)

CHU de Nice; 🇫🇷 Nice, France