Prevalence of Pneumococcal Carriage And Serotype Distribution In Children With Congenital Heart Disease presenting with Pneumonia
Not Applicable
- Conditions
- Health Condition 1: Q89- Other congenital malformations, not elsewhere classifiedHealth Condition 2: J189- Pneumonia, unspecified organism
- Registration Number
- CTRI/2023/06/054227
- Lead Sponsor
- Intramural Research Grant UCMS
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Cases: children (2-59 months) with congenital heart disease confirmed by Echocardiography and presenting with pneumonia defined as per World Health Organisation
Comparison group: children (2-59 months) (preferably age and sex matched) presenting with pneumonia without any known congenital heart defect.
Exclusion Criteria
-children with history of antibiotic intake in past 7 days
-children with known immunodeficiency
-children with chronic kidney and chronic liver disease
-children with nasal deformity
-children with structural lung malformation
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method asopharyngeal carriage of S.pneumoniae in children with pneumonia with & without congenital heart diseaseTimepoint: At baseline
- Secondary Outcome Measures
Name Time Method 1.Serotype distribution & antibiotic resistance of S.pneumoniae. <br/ ><br>2.Association of nasopharyngeal carriage of S.pneumoniae with pneumococcal vaccination. <br/ ><br>3.Risk factors associated with carriage defined as age less than 2 years, malnutrition (weight for height less than -3SD), immunisation status, more than 1 siblings, siblings less than 6 years of age, overcrowding, smoker in family, h/o running nose within last 2 weeks, h/o pneumonia within last 1 year, h/o otitis media within last 1 year, h/o hospitalization within last 1 year. <br/ ><br>4.Association between nasopharyngeal carriage of S.pneumoniae & S.aureus. <br/ ><br>5.Nasopharyngeal & axillary carriage of S.aureus & in vitro antibiotic susceptibility patternTimepoint: At baseline