Effect of capsaicin infusion on esophageal mucosal integrity * a role for TRPV1-mediated neuropeptides? - Capsaicin and mucosal integrity

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 13 人开始时间: 待定最近更新: 2024年2月28日

试验速览

暂无简介。

•Healthy subjects
•I. No history of gastrointestinal disease, especially gastro-esophageal reflux disease.
•II. BMI <= 18-25 kg/m²
•III. Caucasian race
•IV. Subject signed the informed consent form and is able to adhere to study protocol

•Healthy subjects
•I. Age <18 years
•II. Erosive esophagitis or gastric ulceration during endoscopy on PPI in the past or during the experiment.
•III. Use of regular (> 1 x per week) dietary capsaicin or red pepper containing foods.
•IV. Use of medication affecting GI function (prokinetics) or antisecretory medication (PPI) within 3 days prior to endoscopy.
•V. Multisystem diseases (including severe cardiopulmonary disease, collagen diseases, coagulation disorders)
•VI. Esophageal motility disorders
•VII. Previous esophageal or gastric surgery
•VIII. Use of anticoagulants or a history of coagulopathy
•IX. Pregnancy
•X. History of alcohol abuse or current excessive alcohol consumption (> 2 alcoholic beverages per day or > 14 alcoholic beverages per week).
•XI. No allergies for capsaicin.

发起方

Medisch Universitair Ziekenhuis Maastricht