Remineralization Efficacy of Gum Arabic Varnish Versus Fluoride Varnish and CPP-ACP With Fluoride Based Varnish on Initial Carious Lesions. a Randomized Controlled Clinical Trial.
试验速览
- 阶段
- 2 期
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- Remineralization through determination of lesion progression or regression
研究概览
简要总结
The aim of this study is to evaluate the remineralizing capacity of Gum Arabic varnish and its implementation into clinical practice.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 17 Years 至 40 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with initial carious lesions.
- •Proper Oral hygiene.
排除标准
- •Patients with a compromised medical history.
- •Patients with active severe periodontal disease.
- •Patients with hypoplastic or hypomineralized teeth.
研究组 & 干预措施
Gum Arabic varnish
Gum arabic (Acacia senegal) is an exudate obtained from Acacia senegal stems and roots, and other similar African Acacia species. It consists mainly of high molecular weight polysaccharides high concentrations of calcium, magnesium, and potassium salts which can potentially increase tooth remineralization.
干预措施: Gum Arabic varnish (Drug)
Sodium Fluoride varnish
The gold standard remineralizing agent recommended by the guidelines.
干预措施: Proflourid Varnish,VOCO (Drug)
10% w/v CPP-ACP, 5% sodium fluoride varnish
CPP-ACP is the most studied non fluoride remineralizing agent.
干预措施: MI Varnish,GC Japan Inc. (Drug)
结局指标
主要结局
Remineralization through determination of lesion progression or regression
时间窗: Change from baseline at 3,6, 9 months
Determination of lesion level by DIAGNOdent which provides a laser fluorescence feedback to give a numerical readout reflects the amount of demineraliztion.
次要结局
- Caries lesion activity assessment(Change from baseline at 3,6, 9 months)
研究者
Ahmed Hesham samaha
Master's Degree Student- Faculty of Dentistry
Cairo University