Effects of Advanced Glycation Endproducts on Satiety and Inflammation
Not Applicable
Completed
- Conditions
- ObesityType 2 DiabetesInsulin ResistanceCardiovascular Disease
- Interventions
- Other: Dietary meal intervention
- Registration Number
- NCT01434407
- Lead Sponsor
- University of Copenhagen
- Brief Summary
The purpose of the meal study is to investigate acute effects on satiety and inflammation of advanced glycation endproducts (AGE) in healthy overweight subjects. The AGE content of the meal is affected by food preparation methods: frying/grilling versus boiling/steaming.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 19
Inclusion Criteria
- Healthy males and females between 20 and 50 years old
- BMI 25-40
- Waist circumference above 88 cm for women and above 102 cm for men
Exclusion Criteria
- Exercise training above 8 hour/week
- Smoking
- Pregnant or breast-feeding women
- Post-menstrual women
- Regular use of medicine (except contraceptive pills)
- Previous gastric bypass surgery
- Donation of blood within the last 3 months
- Involvement in other clinical trials
- Allergic to paraaminobenzoic acid
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Low AGE meal Dietary meal intervention Test meal prepared by boiling/steaming the food High AGE meal Dietary meal intervention Test meal prepared by frying/grilling the food
- Primary Outcome Measures
Name Time Method Appetite sensation Every 30 min up to 5 hours after test meal Appetite sensation measured by visual analogue scales
Plasma ghrelin Continuous measurement up to 5 hours after test meal Plasma GLP-1 Continuous measurements up to 5 hours after test meal Plasma PYY Continuous measurements up to 5 hours after test meal Plasma insulin Continuous measurements up to 5 hours after test meal Plasma glucose Continuous measurements up to 5 hours after test meal Urine AGE From 24 hour before to 48 hour after test meal
- Secondary Outcome Measures
Name Time Method IL-6 Continuous measurements up to 5 hours after test meal TNF-alpha Continuous measurements up to 5 hours after test meal MIF Continuous measurements up to 5 hours after test meal IL-1 beta Continuous measurements up to 5 hours after test meal Plasma triglycerides Continuous measurements up to 5 hours after test meal Expression of genes related to AGE Continuous measurements up to 24 hours after test meal CRP Continuous measurements up to 5 hours after test meal VCAM Continuous measurements up to 5 hours after test meal ICAM Continuous measurements up to 5 hours after test meal Plasma AGE Continuous measurements up to 48 hours after test meal Urine isoprostanes From 24 hour before to 24 hours after test meal
Trial Locations
- Locations (1)
Department of Human Nutrition, University of Copenhagen
🇩🇰Copenhagen, Frederiksberg C, Denmark