Comparative Evaluation of Newer Congeners i.e. Levobupivacaine and Ropivacaine With Bupivacaine, in Lumbar Epidural Anaesthesia for Hip Surgeries
Overview
- Phase
- Not Applicable
- Intervention
- Bupivacaine
- Conditions
- Pain Insensitivity, Congenital
- Sponsor
- Government Medical College, Haldwani
- Enrollment
- 90
- Locations
- 1
- Primary Endpoint
- Onset of sensory block
- Status
- Completed
- Last Updated
- 10 years ago
Overview
Brief Summary
This study compares the clinical efficacy of newer local anaesthetic drugs Levobupivacaine and Ropivacaine with Bupivacaine in lumbar epidural anaesthesia for hip surgeries.
Detailed Description
Some of the most common day care surgeries are hip surgeries, in which local anaesthetic agents can be used via epidural route for both intra-op and post-op analgesia. Among the drugs used nowadays are Lignocaine, Bupivacaine, Levobupivacaine and Ropivacaine.However Bupivacaine usage is not free from side effects. The claimed benefits of both Levobupivacaine and Ropivacaine are reduced cardiac toxicity on overdose and more specific effects on sensory rather than motor nerve fibres. Ropivacaine, an analog of Mepivacaine, is one of the long acting amide anaesthetic agent similar to Bupivacaine in chemical structure and anaesthetic function. It is a first enantiomer-specific compound, which has a reduced risk of cardio toxicity, neuro toxicity and rapid recovery of motor function. Levobupivacaine is the pure S (-)-enantiomer of Bupivacaine, and in recent year has emerged as a safer alternative for regional anaesthesia than its racemic parent.
Investigators
Dr Subhro Mitra
Assistant Professor
Government Medical College, Haldwani
Eligibility Criteria
Inclusion Criteria
- •ASA Grade I and II patients of either sex
- •Age 18-60 years
- •Undergoing various hip surgeries under lumbar epidural anesthesia
Exclusion Criteria
- •Refusal for epidural
- •ASA-III\&IV
- •Head injury
- •Psychiatric disease
- •Known allergic to test drugs
- •Major systemic disease
- •Any analgesia with in past 24 hours
Arms & Interventions
Bupivacaine & Levobupivacaine
Bupivacaine 15 ml 0.5% and Levobupivacaine 15 ml 0.5% in epidural route before surgery
Intervention: Bupivacaine
Bupivacaine & Levobupivacaine
Bupivacaine 15 ml 0.5% and Levobupivacaine 15 ml 0.5% in epidural route before surgery
Intervention: Levobupivacaine
Bupivacaine & Ropivacaine
Bupivacaine 15 ml 0.5% and Ropivacaine 15 ml 0.75% in epidural route before surgery
Intervention: Bupivacaine
Bupivacaine & Ropivacaine
Bupivacaine 15 ml 0.5% and Ropivacaine 15 ml 0.75% in epidural route before surgery
Intervention: Ropivacaine
Ropivacaine & Levobupivacaine
Ropivacaine 15 ml 0.75% and Levobupivacaine 15 ml 0.5% in epidural route before surgery
Intervention: Levobupivacaine
Ropivacaine & Levobupivacaine
Ropivacaine 15 ml 0.75% and Levobupivacaine 15 ml 0.5% in epidural route before surgery
Intervention: Ropivacaine
Outcomes
Primary Outcomes
Onset of sensory block
Time Frame: 30 minutes
Time to achieve sensory block up to tenth thoracic dermatome
Secondary Outcomes
- Time to achieve maximum motor block(45 minutes)
- Time for 2 segment regression of sensory block(90 minutes)