Trial Examining Methods for Antidepressant Discontinuatio
Phase 4
Recruiting
- Conditions
- 10012375<p>Major Depressive Disorder</p>Paroxetine, venlafaxine, discontinuation, tapering, hyperbolic
- Registration Number
- NL-OMON29528
- Lead Sponsor
- AmsterdamUMC
- Brief Summary
tba
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Om in aanmerking te komen voor deelname aan dit onderzoek, moet een proefpersoon aan alle volgende criteria voldoen:
• Leeftijd 18-75 jaar
Exclusion Criteria
Een potentiële proefpersoon die aan een van de volgende criteria voldoet, wordt uitgesloten van deelname aan dit onderzoek:
• Psychotische/bipolaire stoornis
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The number of patients who are unable to successfully continue to taper the PAR or VLX and stop taking study-medication or take rescue medication</p><br>
- Secondary Outcome Measures
Name Time Method <p>- Withdrawal symptom severity over time (DESS-score) - Depressive symptoms over time (IDS-SR) - Relapse/recurrence rate (MDD diagnosis on MINI interview) and time to event during follow-up - Daily functioning and Quality of life (EQ-5D-5L) - Attitudes towards and perceived difficulty of discontinuation (patient reported) - Cost-effectiveness and productivity losses (TiC-P) - Before and after discontinuation choice and decision times on a task requiring participants to choose how much effort to exert for various amounts of reward</p><br>