Cardiovascular Mechanisms of the Occupational Physical Activity Health Paradox: 24-hour Physical Activity, Blood Pressure, and Heart Rate
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- 24-hour Heart Rate
研究概览
简要总结
This is an observational study to examine the cardiovascular mechanisms of increased cardiovascular mortality in those with high activity occupations.
详细描述
The current proposal uses a repeated-measures, within-subject design to address our aims. Twenty male participants will report to the laboratory to provide informed consent, complete baseline assessments, and receive ambulatory monitors. Following this session, each participant will wear physical activity and ambulatory cardiovascular monitors for 7 days, including at least one non-work day and one work day. Characterization of work activity will use physical activity data from self-reported time at work (Specific Aim I). The 24-hour cardiovascular load (HR and BP) and nocturnal HRV will be compared across work and non-work days (Specific Aim II). Lastly, whether fitness level or job strain modify the difference in cardiovascular strain between work vs. non-work days will be evaluated (Specific Aim III).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 35 Years 至 59 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •middle age (35-59 years)
- •self-report working full-time in the food service industry (≥30 hours/week)
- •self-report predominantly completing light intensity activity job responsibilities (≥75% work time walking, light movement, or standing)
排除标准
- •Resting blood pressure of ≥150 mmHg systolic and/or ≥95 mmHg diastolic
- •currently taking medications that are known to affect blood pressure or heart rate (e.g. Beta-blockers, ACE inhibitors, etc.)
- •greater than low risk to participate in physical activity as determined by PAR-Q (answer of yes to any of the 7 physical activity readiness questionnaire questions)
- •report working a second job in addition to their primary full-time job
- •report working overnight shifts (10pm-6am)
- •reported physical dysfunction (inability to walk 2 city blocks or climb 2 flights of stairs)
- •inability to complete the sub-maximal exercise test to completion (80% age-predicted heart rate maximum)
- •Currently being treated for a serious medical condition such as kidney disease, liver disease, cancer, or heart disease.
结局指标
主要结局
24-hour Heart Rate
时间窗: 24 hours
We will calculate the average heart rate over each 24 hour period throughout a one week monitoring period.
次要结局
- Nocturnal Heart Rate Variability, SDNN(approximately 8 hours (sleep time))
- Nocturnal Heart Rate Variability, LF(approximately 8 hours (sleep time))
- Physical Activity Pattern. MVPA(1 week)
- Nocturnal Heart Rate Variability, RMSSD(approximately 8 hours (sleep time))
- Physical Activity Pattern. LPA(1 week)
- 24-hour Ambulatory Diastolic Blood Pressure(24 hours)
- 24-hour Ambulatory Systolic Blood Pressure(24 hours)
- Physical Activity Pattern. Steps Per Day(1 week)
- Nocturnal Heart Rate Variability, HF(approximately 8 hours (sleep time))
- Physical Activity Pattern. Sedentary(1 week)
- Physical Activity Pattern. Upright(1 week)
研究者
Tyler Quinn
Principle Investigator
University of Pittsburgh