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Clinical Trials/NCT01897350
NCT01897350
Completed
Not Applicable

Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial

Elisa McAlindon1 site in 1 country30 target enrollmentJuly 2013

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
ST Segment Elevation Myocardial Infarction
Sponsor
Elisa McAlindon
Enrollment
30
Locations
1
Primary Endpoint
The mass of myocardial oedema measured by CMR
Status
Completed
Last Updated
11 years ago

Overview

Brief Summary

Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.

Registry
clinicaltrials.gov
Start Date
July 2013
End Date
December 2013
Last Updated
11 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Elisa McAlindon
Responsible Party
Sponsor Investigator
Principal Investigator

Elisa McAlindon

principle investigator

University of Bristol

Eligibility Criteria

Inclusion Criteria

  • providing written informed consent

Exclusion Criteria

  • contraindication to CMR,
  • atrial fibrillation,
  • claustrophobia,
  • eGFR \< 30

Outcomes

Primary Outcomes

The mass of myocardial oedema measured by CMR

Time Frame: Day 2 following STEMI

Secondary Outcomes

  • Extra cellular volume(Day 2 following STEMI)

Study Sites (1)

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