Myocardial Oedema in ST Segment Elevation Myocardial Infarction Myocardial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- ST Segment Elevation Myocardial Infarction
- Sponsor
- Elisa McAlindon
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- The mass of myocardial oedema measured by CMR
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Cardiac magnetic resonance imaging (CMR) is a non invasive technique used to obtain functional and anatomical information on the heart. Several CMR parameters measured after primary percutaneous coronary intervention (PPCI) have been shown to have prognostic value and are increasingly being used as surrogate endpoints in clinical trials. Myocardial oedema is a prognostic indicator following myocardial infarction1. Myocardial salvage is calculated as the myocardial oedema minus infarct size; this again is a prognostic indicator following STEMI. However, myocardial oedema imaging is controversial. There are multiple sequences available, with no standardisation of sequences used to assess this surrogate endpoint. The investigators propose to conduct a study to measure the myocardial oedema by all available techniques to determine the agreement between these methods.
Investigators
Elisa McAlindon
principle investigator
University of Bristol
Eligibility Criteria
Inclusion Criteria
- •providing written informed consent
Exclusion Criteria
- •contraindication to CMR,
- •atrial fibrillation,
- •claustrophobia,
- •eGFR \< 30
Outcomes
Primary Outcomes
The mass of myocardial oedema measured by CMR
Time Frame: Day 2 following STEMI
Secondary Outcomes
- Extra cellular volume(Day 2 following STEMI)