Monocentre evaluation of morphological and neurocognitive alterations after whole brain radiotherapy using IMRT technique with hippocampal sparing and boost to the metastases
- Conditions
- C79.3Secondary malignant neoplasm of brain and cerebral meninges
- Registration Number
- DRKS00003862
- Lead Sponsor
- Klinik für Strahlenheilkunde, Freiburg
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 3
Inclusion Criteria
Patients with 4-8 brain metastases of solid tumors with indication for WBRT
Metastases of 5 - 35mm width
RPA classification I and II
Written informed consent
Exclusion Criteria
Cerebral lymphoma, metastases from germ cell tumors or SLCL
RPA classification III
lack of MRI tolerance
acute neurologic symptoms demanding immediate therapy
accompanying diseases with possible cognitive symptoms or white matter change
antiepileptic medication: benzodiazepine, barbiturate, topiramat, hydantoine, valproic acid, carbamazepin
demetia, depression, diabetes mellitus
hypertensive encephalopathy
metastases within the hippocampus or with 10mm range
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hippocampal volume change (based on MRI) 3 months after therapy
- Secondary Outcome Measures
Name Time Method Change of memory performance (verbal learning) and quality of life, survival, local tumor control