Effect of ischaemic pre-conditioning on cardiac function during elective open abdominal aortic aneurysm repair

Completed

• Conditions: Surgery: Open abdominal aortic aneurysm repair; Surgery; Open abdominal aortic aneurysm repair

• Registration Number: ISRCTN58848790
• Lead Sponsor: Record Provided by the NHSTCT Register - 2006 Update - Department of Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-09-29
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

Any patient scheduled to undergo elective infra-renal aneurysm repair will be eligible for inclusion. The following entry criteria with respect to renal function shall apply:
1. No history of acute renal failure
2. No history of renal replacement therapy (haemodialysis, haemofiltration, peritoneal dialysis)
3. No previous renal transplant
4. No previous renal disease
5. Serum creatinine less than 150 micromols/L at pre-operative assessment
6. Serum urea less than 20 mmols/L at pre operative assessment

Exclusion Criteria

1. Patients with aneurysms above the level of the renal arteries have a very high risk of renal damage during surgery. These aneurysms are relatively uncommon. Their inclusion could bias the trial.
2. Patients with lower limb amputations will be excluded as they have less muscle in their lower limbs. Thus, the IPC stimulus could be inadequate and bias the trial results.
3. Patients with ankle-brachial pressure index < 0.7 will be excluded as the IPC technique could trigger acute lower limb ischaemia.
4. Patients who have undergone previous endovascular repair of the aneurysm will be excluded.

Study & Design

• Study Type: Interventional
• Study Design: Not specified