Evaluation of Efficacy and Safety of General Anesthesia Using Dexmedetomidine With Sevoflurane in Patients Undergoing Arthroscopic Shoulder Surgery: Preliminary Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Yonsei University
- Enrollment
- 19
- Locations
- 1
- Primary Endpoint
- Regional cerebral oxygen saturation value
Study Overview
Brief Summary
Patients undergoing shoulder arthroscopy in the beach chair position may be at risk for adverse neurologic events due to cerebral ischemia.
Dexmedetomidine, a potent alpha adrenoceptor agonist which dose-dependently reduces arterial blood pressure and heart rate, decreases the hemodynamic and catecholamine response in the perioperative period.
dexmedetomidine has an effect of peripheral vasoconstriction thus it is theologically appropriate for reducing bleeding for arthroscopic operation field.
The aim of this study is to evaluate the efficacy and the safety of dexmedetomidine on cerebral oxygen saturation, cognitive function, hemodynamic stability and operative field in patients undergoing arthroscopic shoulder surgery in the beach-chair position.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Prevention
- Masking
- None
Eligibility Criteria
- Ages
- 20 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Aged between 20 and 70 year
- •general anesthesia for arthroscopic shoulder surgery in the beach-chair position
Exclusion Criteria
- •Congestive heart failure, coronary artery occlusive disease
- •Bradycardia < 50 BPM, 2nd degree < AV block
- •Poorly controlled hypertension
- •ß blocker medication
- •Coagulopathy
- •Pregnancy, nursing
Arms & Interventions
dexmedetomidine continuous infusion
Intervention: Dexmedetomidine (Drug)
Outcomes
Primary Outcomes
Regional cerebral oxygen saturation value
Time Frame: T1,T2,T3, T4, T5,T6, T7, T8, T9 time of post-dose during surgery
Before the anesthetic induction(T1), Before endotracheal intubation(T2), After endotracheal intubation(T3), Before the beach-chair position(T4), 5 minutes after the beach-chair position(T5), Before the operation(T6), 5 minutes after the incision(T7), After removal of the arthroscopy(T8), at the end of the operation(T9)
Secondary Outcomes
No secondary outcomes reported