EUCTR2013-001685-42-DK
Active, Not Recruiting
N/A
Changes in coagulation and platelet reactivity in HIV-1 infected patients switching between abacavir and tenofovir containing antiretroviral regimens - TAPAS
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- HIV
- Sponsor
- Rigshospitalet
- Status
- Active, Not Recruiting
- Last Updated
- 11 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •HIV\-1 infected
- •Can understand and sign written informed consent
- •Between 35 and 70 years old at inclusion
- •Received one of the above mentioned antiretroviral regimens continuously \= 6 months
- •HIV RNA \< 400 copies/mL for \= 6 months
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1\.2 Adults (18\-64 years) yes
- •F.1\.2\.1 Number of subjects for this age range 80
- •F.1\.3 Elderly (\>\=65 years) yes
Exclusion Criteria
- •Receiving anticoagulant therapy, ADP\-receptor inhibitors, aspirin or NSAIDs
- •Previous ischemic heart disease, peripheral atherosclerotic disease or stroke
- •Coagulation disorder (e.g. hemophilia, factor V Leiden mutation)
- •Platelet count \< 150 x 109/L during the past 6 months from inclusion
- •eGFR\<70 during the past 6 months from inclusion
- •HLA\-B\*57:01 positive genotype
- •Hepatitis B or C positive during the past year from inclusion
Outcomes
Primary Outcomes
Not specified
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