Arterial Waveform Analysis Applying Different Positive End-Expiratory Pressure (PEEP) Levels in Healthy Volunteers

Not Applicable

Completed

• Conditions: Blood Pressure
• Interventions: Other: progressive increasing of PEEP level.

• Registration Number: NCT03294928
• Lead Sponsor: University of Pisa

Brief Summary

Population in study will be selected from students and staff of the University of Pisa. Right carotid artery contour wave analysis will be performed during the application of different PEEP levels (from 0 cmH2O to 10 cmH2O) with applanation tonometry technique.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-09-19
• Study First Submitted QC: 2017-09-25
• Study First Posted: 2017-09-27
• Study Start: 2017-09-28
• Primary Completion: 2017-10-05
• Study Completion: 2017-10-15
• Status Verified: 2018-01
• Last Update Submitted: 2018-01-04
• Last Update Posted: 2018-01-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 62

Inclusion Criteria

• age between 18 and 40, absence of any chronic diseases, no smoke, no drugs assumptions, no use of caffeine the day of the exam

Exclusion Criteria

• pregnancy, chronic diseases, smokers, and intake of caffeine the day of the exam.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
progressive increasing of PEEP level	progressive increasing of PEEP level.	four-step measurements of central artery blood pressure evaluating contour wave analysis during a progressive increasing of PEEP level.

Primary Outcome Measures

Name	Time	Method
hemodynamic variations in wave reflection induced by the application of increasing levels of PEEP in healthy subjects.	at rest and after 5 minutes	Mean blood pressure

Trial Locations

Locations (1)

University of Pisa; 🇮🇹 Pisa, Italy