Assessment of Hypoxia Inducible Factor and Autophagy Related Genes in Patients With Non-Segmental Vitiligo
Not Applicable
Recruiting
- Conditions
- Vitiligo
- Interventions
- Device: Punch Biopsy 5mm
- Registration Number
- NCT06410898
- Lead Sponsor
- Sohag University
- Brief Summary
The present study will aim to evaluate:
1. The presence of Hypoxia Inducible Factor in vitiligo patient
2. Defect of Autophagy Related Genes in vitiligo patient
3. The cross relation between Autophagy Related Genes and Hypoxia Inducible Factor in the pathogenesis of vitiligo among Egyptian patients in Sohag Governorate
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
- Adult >18 years
- With non segmental vitiligo
- A group of participants will be included as a control group
Exclusion Criteria
- Pregnancy
- Patient with chronic inflammatory skin disorders
- patient on anti-oxidant or anti-inflammatory drugs
- patient on topical or systemic treatment for vitiligo in last 4 weeks
- patients with other autoimmune diseases
- patients with diabetes mellitus
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description skin biopsy from normal skin in normal person Punch Biopsy 5mm punch biopsy 5mm from normal skin patch in normal person skin biopsy from normal skin in vitiligo patient Punch Biopsy 5mm punch biopsy 5mm from normal skin patch in vitiligo patient skin biopsy from vitiligo lesion in vitiligo patient Punch Biopsy 5mm punch biopsy 5mm from vitiligo patch in vitiligo patient
- Primary Outcome Measures
Name Time Method Assessment of Autophagy Related genes in Vitiligo patients 2 months Assess Autophagy Related genes levels in skin biopsy of vitiligo patient
Assessment of Hypoxia Inducible Factor in Vitiligo patients 2 months Assess level of Hypoxia Inducible factor in skin biopsy of vitiligo patient
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Sohag University hospitals
🇪🇬Sohag, Egypt