TCTR20230112004CompletedPhase 2
Comparative study of effectiveness between 20% azelaic acid with low-fluence 1064-nm Nd:YAG picosecond laser and 20% azelaic acid alone in the treatment of melasma in Thai female patients, split-face, prospective study
Institute of Dermatology, Bangkok, Thailand0 sites20 target enrollmentStarted: January 12, 2023Last updated:
Conditions
Trial Snapshot
- Phase
- Phase 2
- Status
- Completed
- Sponsor
- Enrollment
- 20
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Ages
- 18 Years to 65 Years (—)
- Sex
- Female
Inclusion Criteria
- •1)Thai female patients
- •2)Aged 18-65 years old
- •3)Diagnosed with bilateral symmetrical malar type melasma at the face
- •4)Can be able to attend and willing to be a subject in this study including being able to give a consent
Exclusion Criteria
- •1)Taking oral contraceptive pills or receiving hormone replacement
- •2)In the period of pregnancy or lactation
- •3)Have underlying disease of autoimmune diseases such as SLE
- •4)Have underlying disease of thyroid diseases
- •5)Allergy to azelaic acid or preservatives in topical melasma treatment
- •6)Have a laser treatment on the face within 6 months before the study
- •7)Using topical melasma treatments such as kojic acid, hydroquinone, alpha arbutin and whitening agents within 4 weeks before the study
- •8)Treated melasma by chemical peeling agents within 3 months before the study
- •9)Using tranexamic acid or vitamin C within 3 months before the study
- •10) Taking or applying retinoid within 12 months before the study
- •11) Having an active asthma
- •12) Having a history of using antiepileptic drugs
- •13) Having skin infections or any other skin disease, for example, allergic dermatitis, cellulitis, erysipelas, herpes simplex and herpes zoster infection on the face
Investigators
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