A comparison of the efficacy and safety of 0.1% adapalene gel and 0.025% tretinoin cream in the treatment of childhood acanthosis nigricans

Phase 4

Completed

• Conditions: childhood acanthosis nigricans; Acanthosis nigricans; childhood; Topical retinoid

• Registration Number: TCTR20170603001
• Lead Sponsor: Faculty of Medicine, Srinakhariwirot University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-06-03
• Study Completion: 2018-04-30
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

The participants aged 12 -18 years with a diagnosis of acanthosis nigricans

Exclusion Criteria

- Vulnerable skin diseases
- Infectious skin diseases
- Other recent diseases involving the neck
- Other serious medical disorders e.g. DM, liver disease
- Any patients having received other therapies for up to 4 weeks prior to enrollment.
- Photosensitive skin
- Immunocompromised host
- Pregnancy and lactation
- Receiving oral retinoids
- Neck tattoo

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
erythema index and melanin index at the baseline, at week 2, 4 and 8. Mexameter

Secondary Outcome Measures

Name	Time	Method
The efficacy of the treatment at the baseline, at week 2, 4 and 8. investigator’s global evaluation (IGE) scale and the parent’s global evaluation (PGE)