Close to the Bone: An investigation of bone health in young women with Coeliac Disease and non-coeliac gluten sensitivity compared to healthy controls.

Not Applicable

• Conditions: Coeliac disease; Non-coeliac gluten sensitivity; Low bone mineral density; Osteoporosis; Diet and Nutrition - Other diet and nutrition disorders; Inflammatory and Immune System - Autoimmune diseases; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon; Musculoskeletal - Osteoporosis

• Registration Number: ACTRN12619001542189
• Lead Sponsor: Massey University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-11-08
• Last Update Posted: 18 November 2019

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Female
• Target Recruitment: 141

Inclusion Criteria

To become a participant, you will need to:
-Be a healthy female consuming a normal gluten-containing diet.
OR
-Be a female medically diagnosed with coeliac disease (by biopsy), who has consumed a strict gluten free diet for at least 12 months
OR
-Be a female medically diagnosed with non-coeliac gluten sensitivity (i.e. have received a negative diagnosis for coeliac disease by serology and biopsy but have been medically advised to adhere to a GF diet due to improvements in symptoms), who has consumed a strict gluten free diet for at least 12 months
AND
-Be aged between 18-40 years
-Live in the Palmerston North and Wellington Regions

Exclusion Criteria

Previous/current medication affecting bone metabolism (e.g. corticosteroids, bisphosphonates, selective oestrogen receptor modulators); medical conditions affecting bone health; pregnancy and lactation; known history of inflammatory conditions other than CD and NCGS; BMI>30 (derived from screening questionnaire); have not had your condition medically diagnosed according to standard criteria (for the CD and NCGS group).

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Bone mineral density assessed through Dual X-ray Absorptiometry (DXA) and bone quality measured through Quantitative ultrasound (QUS), this is a composite outcome.[Date of research unit visit]