The rate of glucose uptake over the blood-brain barrier in humans in vivo, measured by 13C magnetic resonance spectroscopy

Completed

• Conditions: Diabetes; Diabetes Mellitus; 10018424

• Registration Number: NL-OMON36330
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 16

Inclusion Criteria

All volunteers:
age between 18-60 years;Patients with Type 1 Diabetes Mellitus:
Stable glycaemic control with HbA1c 6.5-9.0%
Duration of diabetes >5 years

Exclusion Criteria

All volunteers:
History of epilepsia or operations of the brain
Metal implants or pace-maker;Patients:
All complications of Diabetes except background retinopathy
Hypoglycemia unawareness
Medication other then oral anti-conceptiva or thyroxine supplements

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>• the time difference between the cerebral 13C glucose peak and the blood<br /><br>glucose peak after intravenous glucose loading</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>• areas under the cerebral 13C glucose and blood glucose response curve<br /><br>• times until 13C glucose and blood glucose have returned to baseline values</p><br>