Pulmonary Diffusing Capacity Changes to Posture and Acute Exercise in Healthy Volunteers: a Randomised Test-retest Relaibility Study
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Rigshospitalet, Denmark
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- Between intervention DLCO repeatability coefficient
Study Overview
Brief Summary
The combined measurement of the pulmonary diffusing capacity to carbon monoxide (CO) and nitric oxide (NO) (DLCO/NO) has recently been standardised and validated for clinical use. It involves a very short breath-hold time (≤5 seconds), and it may be repeated up to 12 times without affecting measurements, and it is thus ideal for assessing acute changes in pulmonary diffusing capacity and its components during various physiological manoeuvres. The aim of the present study is to compare the test-retest reliability of pulmonary diffusing capacity measurements during postural changes (sitting vs. supine) vs. rest-to-exercise. DLCO/NO will either be measured in the sitting position during rest vs. exercise or in the sitting and supine posture, and this will be repeated within 1-7 days in 20 healthy individuals that will be randomised to one of the two interventions. Statistically,the test-retest relaibility of sitting-to-supine vs. rest-to-exercise changes in DLCO/NO will be compared by parametric methods.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Regular exercise (1-3 timer per week)
Exclusion Criteria
- •Any known medical condition that requires regular medication or any known lung condition
- •Symptoms of disease within 2 weeks prior to the study
- •Abnormal lung function test
- •Pregnancy
Arms & Interventions
Rest-to-exercise
Intervention: Rest-to-exercise (Diagnostic Test)
Sitting-to-supine
Intervention: Sitting-to-supine (Diagnostic Test)
Outcomes
Primary Outcomes
Between intervention DLCO repeatability coefficient
Time Frame: 1 week
Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DLCO
Between intervention DLNO repeatability coefficient
Time Frame: 1 week
Test-retest repeatability coefficient of rest-to-exercise and supine-to-prone DLNO
Between intervention DLNO/DLCO-ratio repeatability coefficient
Time Frame: 1 week
Test-retest reliability coefficient of rest-to-exercise and supine-to-prone DLNO/DLCO-ratio
Secondary Outcomes
- Between intervention DM repeatability coefficient(1 week)
- Between intervention Vc repeatability coefficient(1 week)
Investigators
Ronan Berg
Associate Professor
Rigshospitalet, Denmark