Effect of Nigella Sativa on Lipid Profiles in Elderly
- Conditions
- Dyslipidemia
- Interventions
- Drug: Nigella sativeDietary Supplement: black sticky rice
- Registration Number
- NCT01531062
- Lead Sponsor
- Indonesia University
- Brief Summary
The purpose of this study is to determine whether Nigella sativa seed extracts are effective in the treatment of dyslipidemia in elderly.
- Detailed Description
Cardiovascular diseases are still common health problems worldwide. They are major causes of morbidity and mortality in many countries. Dyslipidemia is the main risk factor of cardiovascular events. Despite the invention of many conventional hypolipidemic drugs, the use of traditional medicine remains high, especially in elderly patients. However, evidence of the effectiveness of many herbs or other traditional drugs is lacking. Nigella sativa or black seeds are traditional herbs used for years in Middle East and India. They are believed to cure many diseases, including dyslipidemia. Therefore, a study is needed to prove their effectiveness as their use might improve our strategy to improve patients' compliance.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 96
- age of 60 years or more
- having dyslipidemia (total cholesterol >200 mg/dL or LDL >100 mg/dL or triglyceride > 150 mg/dL or HDL < 40 mg/dL (male) or HDL < 50 mg/dL (female)
- ALT or AST are two times of upper normal limit
- creatinine clearance test is below 30
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Nigella sativa Nigella sative Nigella sativa extracts, 300 mg twice daily Placebo black sticky rice -
- Primary Outcome Measures
Name Time Method Decreased level of total cholesterol, LDL, dan triglyceride, and increased level of HDL 56 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Internal Medicine Department, Faculty of Medicine, University Indonesia
🇮🇩Jakarta, Indonesia