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临床试验/NCT03665805
NCT03665805已完成不适用

Neuromuscular Monitoring, Reversal of Block and Postoperative Residual Curarization: the Situation in 2018

Onze Lieve Vrouw Hospital1 个研究点 分布在 1 个国家目标入组 587 人开始时间: 2018年7月30日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
587
试验地点
1
主要终点
Incidence of postoperative residual curarisation

研究概览

简要总结

The primary objective of this study is to evaluate the incidence of postoperative residual curarization, as defined by a train-of-four <90%, upon postanaesthesia care unit arrival. Anesthetists tend to use train-of-four monitoring in the operating theatre to interpret muscle tone. Train-of-four monitoring is a widely used term for the peripheral nerve stimulation used in neuromuscular blockade monitoring. Hypothesizing a change in our practice since 2006-2012 (Cammu G, Anesth Analg 2006; 102: 426-9 and Cammu G, Anaesth Intensive Care 2012; 40: 999-1006), residual neuromuscular block as well as the use of intraoperative neuromuscular transmission monitoring and reversal of neuromuscular blocking agents will again be prospectively evaluated in 2018. The present study aims to compare these three periods (2006-2012-2018) in terms of management of neuromuscular block in the operating room and to look for a relationship with the incidence of postoperative residual curarization.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18 years of age or older;
  • Informed consent signed;
  • Admission for elective surgery;
  • Administration of non-depolarizing neuromuscular blocking agents during surgery;
  • Tracheal intubation

排除标准

  • Evidence of renal, hepatic, metabolic, and/or neuromuscular disorders
  • Ejection fraction <20%
  • Admission for emergency surgery; or cardiothoracic surgery
  • Reoperation during the same hospital admission

结局指标

主要结局

Incidence of postoperative residual curarisation

时间窗: Immediately after the patients' arrival in the post-anesthesia care unit (<5 min after arrival), two consecutive neuromuscular transmission measurements (separated by 15 s) will be obtained, and the average of the 2 values will be recorded.

Incidence of postoperative residual curarisation defined by a train-of-four (TOF) ratio \< 0,9 at post-anesthesia care unit arrival

次要结局

未报告次要终点

研究者

发起方
Onze Lieve Vrouw Hospital
申办方类型
Other
责任方
Principal Investigator
主要研究者

Guy CAMMU

Staff Anesthesiologist

Onze Lieve Vrouw Hospital

研究点 (1)

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