on-invasive structure-function assessment of the liver by 2D time-harmonic elastography and the dynamic Liver MAximum capacity (LiMAx) test

Recruiting

• Conditions: iver fibrosis, Liver cirrhosis, Hepatocellular carcinoma, Colon carcinoma metastasis, Cholangiocarcinoma; K74; C22; C78; Fibrosis and cirrhosis of liver; Malignant neoplasm of liver and intrahepatic bile ducts; Secondary malignant neoplasm of respiratory and digestive organs

• Registration Number: DRKS00016362
• Lead Sponsor: Charité Campus Virchow-Klinikum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-01-14
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 97

Inclusion Criteria

Healthy test person = 18 years old;
Patients = 18 years old admitted to the hospital for liver surgery or liver transplantation;
Participants who gave their written informed consent

Exclusion Criteria

Patients with history of liver transplantation; Patients with a portosystemic shunt; Patients with a known paracetamol allergy; Patients with known coronary heart disease; Patients with severe infectious disease or fever >38.5°; Patients who are unable to cooperate during the study (e.g. mental dysfunction or drug abuse)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
liver function / structure relationship (function assessed at enrollment by the Liver MAximum capacity (LiMAx) test and tissue stiffness by 2D time-harmonic elastography (THE))

Secondary Outcome Measures

Name	Time	Method
Influence of the bicarbonate kinetic on the result of the LiMAx liver function test