The Safety & Efficacy of Terlipressin vs Octreotide for the Control of Variceal Bleed
- Conditions
- Portal HypertensionCirrhosisHematemesisMelena
- Interventions
- Registration Number
- NCT00534677
- Lead Sponsor
- Aga Khan University
- Brief Summary
Terlipressin and Octreotide are two common agents used as adjuvants in the management of variceal bleeding. Both agents have been claimed equivalent to endoscopic therapy in randomized studies. There are no head to head clinical trials of these two agents available in the literature. We aimed to compare the efficacy and safety of Terlipressin and Octreotide in combination with Endoscopic Variceal band Ligation (EVL)in patients presenting with Esophageal Variceal Bleed (EVB).
- Detailed Description
The effectiveness of combining Endoscopic treatment with Octreotide or Terlipressin has not been prospectively studied in esophageal variceal hemorrhage (EVH).
This prospective, randomized clinical trial will help us in better patient management more efficiently and cost effectively.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 320
- All cirrhotic patients with upper GI bleed secondary to esophageal varices of 18 years or more of age
- Ulcerative esophagitis,
- Mallory Weiss tear,
- Bleeding gastric or duodenal ulcers,
- Bleeding from gastric varices or portal hypertensive gastropathy and
- Upper GI bleed as a result of thrombocytopenia or bleeding diathesis.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description A Terlipressin - B Octreotide -
- Primary Outcome Measures
Name Time Method Safety & Efficacy 5 days
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
The Aga Khan University Hospital
🇵🇰Karachi, Sindh, Pakistan