The Methylation Level of the Orexin Gene in Anorexia Nervosa: Relationship With Eating Disorder, Depressive State, and Sleep Quality
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Orexin A promoter methylation
研究概览
简要总结
The objectives of this study will be to determine the methylation of the promoter of the Orexin A (OX-A) and B (OX-B) genes in young women (> 18 years) with Anorexia Nervosa (AN), compared with a control group; and to evaluate the relationship of promoter methylation of the genes for OX-A and OX-B with the severity of the eating disorder, psychiatric comorbidities (in particular, depression), and sleep quality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Patients with Anorexia Nervosa:
- •Inclusion Criteria:
- •Female sex
- •Age 18 years and older
- •Anorexia Nervosa
- •Hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy
排除标准
- •Absence of signed informed consent
- •Control group:
- •Inclusion Criteria:
- •Female sex
- •Age 18 years and older
- •Body Mass Index between 18.5 and 24.9 kg/m2
- •Exclusion Criteria:
- •Absence of signed informed consent
- •Presence of any physical and mental pathology
研究组 & 干预措施
Anorexia Nervosa
Young women with Anorexia Nervosa, hospitalized at the Division of Eating and Nutrition Disorders, Istituto Auxologico Italiano, IRCCS, Piancavallo, Italy,
干预措施: Blood samples and Questionnaires (Other)
Normal weight
Young women of comparable age with Body Mass Index between 18.5 and 24.9 kg/m2
干预措施: Blood samples and Questionnaires (Other)
结局指标
主要结局
Orexin A promoter methylation
时间窗: Baseline
Percentage of Orexin A promoter methylation
Orexin B promoter methylation
时间窗: Baseline
Percentage of Orexin B promoter methylation
次要结局
未报告次要终点