Weight-Bearing Magnetic Resonance Imaging (MRI) for Analysis of Knee Osteoarthritis (OA)

Completed

• Conditions: Osteoarthritis
• Interventions: Radiation: X-ray; magnetic resonance imaging

• Registration Number: NCT00665548
• Lead Sponsor: University of California, San Francisco

Brief Summary

The purpose of the study is to use different x-ray and magnetic resonance (MR) imaging techniques to take pictures of the knee. There are two specific purposes to the study:

1. whether the different x-ray and MRI techniques will give the same or different information about the knee joint and

2. which part of the knee joint will show the biggest change using the different x-ray and MRI techniques. The study is not designed to test a hypothesis.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Status Verified: 2008-03
• Study Start: 2008-03
• Study First Submitted: 2008-04-22
• Study First Submitted QC: 2008-04-23
• Study First Posted: 2008-04-24
• Primary Completion: 2009-02
• Study Completion: 2009-02
• Last Update Submitted: 2009-04-16
• Last Update Posted: 2009-04-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 33

Inclusion Criteria

• Female
• 40 years and older
• Subjects who are willing and able to comply with x-ray and MRI procedures
• Evidence of a personally signed and dated consent document

Additional inclusion for normal controls:

• Infrequent knee pain, aching, or stiffness during the past year or infrequent use of medication for treatment of knee pain during the past year
• No evidence of OA on either knee (i.e. K-L grade = 0 diagnosed by knee radiography)

Additional inclusion for OA patients:

• Pain, aching, or stiffness on most days of a month during the past year; or use of medication for treatment of knee pain on most days of a month during the past year
• Kellgren-Lawrence Grade 2 or 3 of the study knee obtained on a Standard knee radiograph (with either the same or less severe OA, or no OA in the contralateral knee)

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Exclusion Criteria

• Subject is unable to undergo MRI because of contraindication
• Women at risk of pregnancy
• Weight greater than 250 lbs
• History of surgery in the study knee
• History of other diseases involving the study knee joint including inflammatory joint diseases, crystalline disease, and infection of the study knee

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Normal Subjects	X-ray; magnetic resonance imaging	Female subjects scoring Kellgren \& Lawrence grade 0.
OA Subjects	X-ray; magnetic resonance imaging	Female subjects with Kellgren \& Lawrence score of 2 or 3.

Primary Outcome Measures

Name	Time	Method
Determine which joint components demonstrate the greatest changes between weight-bearing and non weight-bearing protocols.	at time of scan

Secondary Outcome Measures

Name	Time	Method
Determine if additional information gained from weight-bearing images can explain the difference in joint space width (JSW) between weight-bearing x-ray and traditional non-weight bearing MRI.	at time of scan

Trial Locations

Locations (1)

University of California - San Francisco; 🇺🇸 San Francisco, California, United States