NCT00665548已完成不适用
Weight-Bearing MRI for Analysis of Knee OA
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 试验地点
- 1
- 主要终点
- Determine which joint components demonstrate the greatest changes between weight-bearing and non weight-bearing protocols.
研究概览
简要总结
The purpose of the study is to use different x-ray and magnetic resonance (MR) imaging techniques to take pictures of the knee. There are two specific purposes to the study:
- whether the different x-ray and MRI techniques will give the same or different information about the knee joint and
- which part of the knee joint will show the biggest change using the different x-ray and MRI techniques. The study is not designed to test a hypothesis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •40 years and older
- •Subjects who are willing and able to comply with x-ray and MRI procedures
- •Evidence of a personally signed and dated consent document
- •Additional inclusion for normal controls:
- •Infrequent knee pain, aching, or stiffness during the past year or infrequent use of medication for treatment of knee pain during the past year
- •No evidence of OA on either knee (i.e. K-L grade = 0 diagnosed by knee radiography)
- •Additional inclusion for OA patients:
- •Pain, aching, or stiffness on most days of a month during the past year; or use of medication for treatment of knee pain on most days of a month during the past year
- •Kellgren-Lawrence Grade 2 or 3 of the study knee obtained on a Standard knee radiograph (with either the same or less severe OA, or no OA in the contralateral knee)
排除标准
- •Subject is unable to undergo MRI because of contraindication
- •Women at risk of pregnancy
- •Weight greater than 250 lbs
- •History of surgery in the study knee
- •History of other diseases involving the study knee joint including inflammatory joint diseases, crystalline disease, and infection of the study knee
结局指标
主要结局
Determine which joint components demonstrate the greatest changes between weight-bearing and non weight-bearing protocols.
时间窗: at time of scan
次要结局
- Determine if additional information gained from weight-bearing images can explain the difference in joint space width (JSW) between weight-bearing x-ray and traditional non-weight bearing MRI.(at time of scan)
研究者
研究点 (1)
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