Optimization of Cardiac Resynchronization Therapy by Non-Invasive Imaging of Cardiac Electrophysiology: A Pilot Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Heart Failure
- Sponsor
- Medical University Innsbruck
- Enrollment
- 25
- Locations
- 1
- Primary Endpoint
- Optimal (shortest) activation time of the right and left ventricular in heart failure patients after CRT implantation
- Status
- Recruiting
- Last Updated
- 7 months ago
Overview
Brief Summary
The principal aim is to analyze total left and right ventricular activation time in different CRT device programming algorithms (SyncAV) measured by non-invasive electrophysiology
Detailed Description
Patient specific anatomic parameters taken from the cardiac magnetic resonance examination will be the base for a semiautomatic model incorporating the conductivity of the heart, the lungs, blood and the torso. For this reason, a software package (AMIRA Developer, TGS Template Graphics Software, France) has been adapted to calculate a quasi static approximation of Maxwell equations. After fusion of the T1 CMR scan and the ECG electrodes a model-based bidomain FEM is used for a step-wise measurement of the local activation times (resting potential: 290 mV; plateau: 0 mV; acceleration time: 3 ms) both Ende- and epicardially.
Investigators
Eligibility Criteria
Inclusion Criteria
- •patients after successful implantation of a CRT-D or CRT-P device in whom a cardiac magnetic resonance examination is possible and the device is equipped with the SyncAV® programming software
- •left bundle branch block before CRT implantation
- •PQ interval ≤ 250 ms before implantation
Exclusion Criteria
- •high-grade AV block
- •any contraindication concerning a safe CMR performance including claustrophobia
- •terminal heart failure (NYHA IV) or cardiac decompensation
- •life expectancy \< 1 year
- •women with child-bearing potential, pregnancy
- •drug abusus
Outcomes
Primary Outcomes
Optimal (shortest) activation time of the right and left ventricular in heart failure patients after CRT implantation
Time Frame: The measurements will be done at Day 1
The activation time will be measured in 16 different device programming settings