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Clinical Trials/NCT00145678
NCT00145678
Completed
Phase 2

Psychodynamic Therapy for Patients With Borderline Personality Disorder and Alcohol Abuse

State University of New York - Upstate Medical University1 site in 1 country30 target enrollmentJune 2004

Overview

Phase
Phase 2
Intervention
Not specified
Conditions
Borderline Personality Disorder
Sponsor
State University of New York - Upstate Medical University
Enrollment
30
Locations
1
Primary Endpoint
episodes of parasuicide, alcohol intoxication, institutional care
Status
Completed
Last Updated
11 years ago

Overview

Brief Summary

The purpose of the study is to determine the feasibility and effectiveness of a modified form of psychodynamic psychotherapy for persons suffering from co-occurring borderline personality disorder and an alcohol use disorder.

Detailed Description

Borderline Personality Disorder (BPD) is a condition that can cause significant distress and increased risk of death. Many persons with BPD also have an alcohol use disorder (AUD) and there is evidence that this can worsen the outcome and course of both disorders. A manual-based form of psychodynamic therapy (PT), labeled dynamic deconstructive psychotherapy, has been developed for particularly challenging patients with BPD, especially those with co-occurring substance use disorders. It aims to remediate specific neurocognitive capacities that are responsible for processing of emotional experiences, and so diminishes symptoms of BPD and promotes the development of a coherent and differentiated self-structure. PT has been shown to be helpful for BPD, but has not been tested for people who have BPD with co-occurring substance use disorders. The proposed study is a randomized controlled trial of PT for persons with BPD and co-occurring AUD that will generate some initial data that can be used to determine the need and feasibility for further outcome studies. Participants are randomized to either a study group receiving weekly PT or to a control group receiving usual care. Enrollment is 15 participants in each group. The study group will receive 12-18 months of PT, with naturalistic follow-up. Outcome measures are administered by a research assistant at enrollment, 3 months, 6 months, 9 months, 12 months, and 30 months. The investigators anticipate that the PT group will show trends towards better retention in treatment and greater reduction in parasuicides, alcohol misuse, and institutional care. If so, this would have important and positive implications for the large group of patients who suffer from BPD and co-occurring AUD.

Registry
clinicaltrials.gov
Start Date
June 2004
End Date
May 2010
Last Updated
11 years ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Sponsor
State University of New York - Upstate Medical University
Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • Age between 18 and 45 years
  • Meets diagnostic criteria for borderline personality disorder and for active alcohol abuse or dependence
  • At least average intelligence

Exclusion Criteria

  • Meets diagnostic criteria for schizophrenia, or schizoaffective disorder

Outcomes

Primary Outcomes

episodes of parasuicide, alcohol intoxication, institutional care

Time Frame: 12 months

Secondary Outcomes

  • depression, dissociation, core symptoms of borderline pd, perceived social support(12 months)

Study Sites (1)

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