Intubating Conditions During Propofol-remifentanil Anesthesia With Topical Lidocaine

Not Applicable

Completed

• Conditions: Drug Usage
• Interventions: Drug: normal saline; Drug: lidocaine

• Registration Number: NCT01489683
• Lead Sponsor: Ajou University School of Medicine

Brief Summary

When not using neuromuscular blocking agent, even at optimal dosage, target-controlled infusion (TCI) of propofol and remifentanil occasionally produce unsatisfactory intubating conditions. Therefore, the investigators evaluated that the effect of tracheal lidocaine on the intubating conditions for tracheal intubation during anesthesia induction of propofol and remifentanil TCI without neuromuscular blocking agent in day-case anesthesia.

Detailed Description

Anesthesia was induced with propofol-remifentanil TCI with the effect-site concentration of 5μg/ml and 5ng/ml, respectively. After TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, following intubation was performed.

Study Timeline

• Study Start: 2011-05
• Study First Submitted: 2011-12-07
• Study First Submitted QC: 2011-12-09
• Study First Posted: 2011-12-12
• Primary Completion: 2012-04
• Study Completion: 2012-05
• Status Verified: 2012-07
• Last Update Submitted: 2012-07-13
• Last Update Posted: 2012-07-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• ASA I, II patients undergoing general anesthesia for reduction of nasal bone fracture

Exclusion Criteria

• bronchial asthma,
• COPD,
• hypertension,
• anticipated difficult airway

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
lidocaine	normal saline	3 ml of 4% lidocaine was instilled to larynx and trachea before endotracheal intubation
control	lidocaine	3 ml of normal saline was instilled to larynx and trachea

Primary Outcome Measures

Name	Time	Method
Overall acceptable conditions for tracheal intubation	baseline from 5 min of TCI was maintained	Four minutes after start of propofol-remifentanil TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, and one minute later, intubation was performed in double-blinded fashion.

Trial Locations

Locations (1)

Ajou University School of Medicine; 🇰🇷 Suwon, Korea, Republic of