Effect of Tracheal Lidocaine on Intubating Conditions During Propofol-remifentanil TCI Without Neuromuscular Blockade
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Overall acceptable conditions for tracheal intubation
研究概览
简要总结
When not using neuromuscular blocking agent, even at optimal dosage, target-controlled infusion (TCI) of propofol and remifentanil occasionally produce unsatisfactory intubating conditions. Therefore, the investigators evaluated that the effect of tracheal lidocaine on the intubating conditions for tracheal intubation during anesthesia induction of propofol and remifentanil TCI without neuromuscular blocking agent in day-case anesthesia.
详细描述
Anesthesia was induced with propofol-remifentanil TCI with the effect-site concentration of 5μg/ml and 5ng/ml, respectively. After TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, following intubation was performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA I, II patients undergoing general anesthesia for reduction of nasal bone fracture
排除标准
- •bronchial asthma,
- •hypertension,
- •anticipated difficult airway
研究组 & 干预措施
control
3 ml of normal saline was instilled to larynx and trachea
干预措施: lidocaine (Drug)
lidocaine
3 ml of 4% lidocaine was instilled to larynx and trachea before endotracheal intubation
干预措施: normal saline (Drug)
结局指标
主要结局
Overall acceptable conditions for tracheal intubation
时间窗: baseline from 5 min of TCI was maintained
Four minutes after start of propofol-remifentanil TCI, 3 ml of normal saline or 3 ml of 4% lidocaine was instilled to larynx and trachea, and one minute later, intubation was performed in double-blinded fashion.
次要结局
未报告次要终点
研究者
Jong Yeop Kim
Associate professor
Ajou University School of Medicine