Pilot Study of Effect of Intravenous Lidocaine on Propofol Requirement During Monitored Anesthesia Care in Facial Plastic Surgery
Overview
- Phase
- Phase 4
- Intervention
- lidocaine
- Conditions
- Anesthesia, Intravenous; Surgery, Plastic
- Sponsor
- Chung-Ang University Hosptial, Chung-Ang University College of Medicine
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- total propofol requirements
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The purpose of this randomized pilot study is to evaluate the effect of intravenous lidocaine on propofol requirement during BIS (Bispectral index) guided MAC (monitored anesthesia care) in facial plastic surgery.
Detailed Description
Several studies reported the usefulness of intravenous lidocaine as a coadjuvant agent during general anesthesia. We thought that there would be an interaction between intravenous lidocaine and hypnotic agent requirement. However, there is no data regarding the effect of systemic lidocaine during MAC. We, thus, would like to perform a randomized, double-blinded pilot study to evaluate the effect of intravenous lidocaine on propofol requirement during BIS guided MAC in facial plastic surgery.
Investigators
Chongwha Baek
Professor
Chung-Ang University Hosptial, Chung-Ang University College of Medicine
Eligibility Criteria
Inclusion Criteria
- •American Society of Anesthesiologists physical status classification 1 or 2 patients
- •aged 20-65 years who were undergoing elective facial plastic surgery under monitored anesthesia care
Exclusion Criteria
- •unwillingness to participate in the study
- •adverse reaction to the drugs used in the study
- •use of medications that interfere in local anesthetic metabolism
- •history of liver disease or kidney failure
- •neurological or psychiatric disease
- •history of drug or alcohol abuse
- •chronic use of benzodiazepine
Arms & Interventions
Lidocaine group
Patients will be received an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.
Intervention: lidocaine
Lidocaine group
Patients will be received an intravenous bolus injection of 1.5 mg/kg lidocaine followed by a continuous lidocaine infusion of 2 mg/kg/hr.
Intervention: propofol
Control group
Patients will be received an intravenous bolus injection of 1.5 mg/kg normal saline followed by a continuous normal saline infusion of 2 mg/kg/hr.
Intervention: normal saline
Control group
Patients will be received an intravenous bolus injection of 1.5 mg/kg normal saline followed by a continuous normal saline infusion of 2 mg/kg/hr.
Intervention: propofol
Outcomes
Primary Outcomes
total propofol requirements
Time Frame: during monitored anesthesia care
Patients' sedation depth will be monitored using a BIS monitor. Propofol will be administered using target controlled infusion (TCI) from targeting 60 to 80 of BIS. At the end of surgery, total propofol requirements will be examined and collected.
Secondary Outcomes
- postoperative pain(30 minutes, 2 hours, and 4 hours after surgery)