Peripartal Coagulation -Impact of prepartum concentration of fibrinogen on the clot formation and the thromboelastometry derived parameters (ROTEM®) with regard to the partal blood loss

• Conditions: peripartal coagulation, post partum haemorrhage (PPH)PPH in combination with fibrinogen concentration, parameters of plasmatic coagulation and partal blood loss; O72; Postpartum haemorrhage

• Registration Number: DRKS00005624
• Lead Sponsor: Charitè Universitätsmedizin Berlin Klinik für Anästhesiologie m.S. operative Intensivmedizin

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2013-05-31
• Study Start: 2014-02-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 217

Inclusion Criteria

pregnant women at admission to the labor ward for vaginal delivery
- minimum age 18 years
- consent of women for use of personal data

Exclusion Criteria

- not able to speak and understand german
- doubt of ability to judge

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Prepartal determination of Maximum Clotting Formation (MCF) in the Fibtem® test (ROTEM® ,TEM, München) and fibrinogen concentration (measured according to Clauss) <br><br>2. Intrapartum measurement of blood loss systematically by a calibrated drape under buttocks (Brenner Medical, München) <br>

Secondary Outcome Measures

Name	Time	Method
1. Determination of MCF in the Fibtem® test (ROTEM® analysis) and fibrinogen concentration after delivery and 48 h postpartum<br>2. Determination of Clotting Time (CT) and Clotting Formation Time (CFT) in the INTEM® test (ROTEM® analysis) pre- and postpartal (after delivery and 48h postpartum)<br>3. Different viscoelastic parameters ( CT, CFT, alpha angle ) of ROTEM® analysis (INTEM®, EXTEM®, APTEM®)<br>