Glucose and Lipid Metabolism in Adolescents

• Conditions: Insulin Sensitivity; Obesity; Exercise
• Interventions: Behavioral: Exercise

• Registration Number: NCT00998855
• Lead Sponsor: National Institutes of Health (NIH)

Brief Summary

A 12 wk aerobic exercise program will reduce visceral, hepatic and intramyocellular fat accumulation and improve insulin sensitivity and glucose metabolism in obese sedentary Hispanic adolescents.

Detailed Description

Lean and Obese post pubertal adolescents perform an aerobic exercise program 30 minx4/week at a heart rate corresponding to at least 70% of that obtained at VO2 peak. The exercise program is preceded and followed by a 7 d diet delivered by the metabolic research kitchen (identical on both study occasions); metabolic studies (identical on both study occasions) including 24h calorimetry, measurements of glucose and lipid metabolism and insulin sensitivity and secretion using compounds labelled with stable i.e. non radioactive isotopes and gas chromatography-mass spectrometry.Fat mass and lean body mass are measured by DXA and visceral/subcutaneous, hepatic and intramyocellular fat by MRI/MRS. Since we want to specifically determine the effects of exercise, there is no intent of weight loss. The subjects are weighed twice a week to assure weight stability.

Study Timeline

• Study Start: 2004-02
• Status Verified: 2009-10
• Study First Submitted: 2009-10-20
• Study First Submitted QC: 2009-10-20
• Study First Posted: 2009-10-21
• Last Update Submitted: 2011-06-06
• Last Update Posted: 2011-06-07
• Primary Completion: 2011-12
• Study Completion: 2011-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Healthy
• No medication
• Sedentary
• No first degree relative with diabetes,
• Hispanic
• BMI >30 or <25 kg/m2.

Exclusion Criteria

• Any medication including birth control pills
• Performing more than >45 min of moderate to light physical activity/week
• Chronic illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Adolescents	Exercise	Post pubertal, sedentary lean and obese Hispanic adolescents

Primary Outcome Measures

Name	Time	Method
Fat distribution, insulin sensitivity, glucose production, gluconeogenesis, glycogenolysis	In response to a 12 wk exercise program.

Secondary Outcome Measures

Name	Time	Method
Lipolysis, blood lipids, adiponectin, leptin and CRP	In response to a 12 wk exercise program

Trial Locations

Locations (1)

Baylor College of Medicine; 🇺🇸 Houston, Texas, United States