Neuro-urological Outcome After Spinal Cord Injury
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Urodynamic evaluation
研究概览
简要总结
Most patients with spinal cord injury suffer from bladder dysfunction which may - especially in the long-term - impair renal function. Improved treatment during the last decades improved life expectancy and quality of life. This study evaluates the bladder function in the long-term after spinal cord injury.
详细描述
Bladder dysfunction is a common consequence of spinal cord injury and depends on the completeness and the level of the lesion. Patients with suprasacral injury usually suffer from neurogenic detrusor overactivity mostly combined with detrusor sphincter dyssynergia. Without adequate treatment, this adverse combination puts the upper urinary tract at risk due to high intravesical pressure often causing vesico-ureteral reflux. Based on improved therapeutic options in the last decades, life expectancy and quality of life constantly increased in spinal cord injury patients. The investigators aim to evaluate the bladder function in the long-term after spinal cord injury.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Spinal cord injury for at least 5 years
- •Neurogenic lower urinary tract dysfunction
- •Written informed consent
排除标准
- •Lower urinary tract dysfunction due to other causes than spinal cord injury
结局指标
主要结局
Urodynamic evaluation
时间窗: 5 years after SCI, yearly thereafter (participants are followed until death)
Max. cystometric capacity, compliance, detrusor leak point pressure
次要结局
- imaging of the upper urinary tract(5 years after SCI, yearly thereafter (participants are followed until death))
- secondary complications(5 years after SCI, yearly thereafter (participants are followed until death))
研究者
Thomas Kessler
PD Dr. med.
Balgrist University Hospital