NCT06669026已完成2 期
Therapeutic Efficacy of Local Vitamin D Drug as an Adjunct to Mechanical Debridement in the Treatment of Periodontitis
适应症
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Periodontal Assessment
研究概览
简要总结
The proposed study aims to investigate the impact of adjunctive vitamin D gel application on gingival crevicular fluid levels of alkaline phosphatase and interleukin-8 in periodontitis patients undergoing phase 1 periodontal therapy. By elucidating the molecular mechanisms underlying the therapeutic effects of vitamin D, this research seeks to contribute to the development of more effective treatment strategies for periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with attachment loss 3-4 mm
- •periodontal pocket ≤ 5 mm
排除标准
- •- Patients with sensitivity to the medication used in the study.
- •Patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study.
- •Patients with systemic diseases.
- •Pregnant and lactating females.
- •Smokers and tobacco chewers.
- •Patients not compliant with oral hygiene procedures.
结局指标
主要结局
Periodontal Assessment
时间窗: 12 weeks
Periodontal Index
次要结局
- Interleukin 8(8 weeks)
- alkaline phosphatase(8 weeks)
研究者
研究点 (2)
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