Effects of a Resistance Training Period on Blood Pressure of Hypertensive Elderlies: Influence of the Polymorphism of the Angiotensin Converting Enzyme
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 136
- 试验地点
- 1
- 主要终点
- Blood Pressure
研究概览
简要总结
The study aimed to evaluate the chronic effects of resistance training on blood pressure and biochemical exams in hypertensive elderlies and the influence of the polymorphism of the angiotensin converting enzyme in these response.
详细描述
To investigate the chronic effects of resistance training on blood pressure and biochemical exams in elderly, 135 hypertensive elderlies were divided into 2 groups: trained and control. The trained group was submitted to a resistance training period. Before the 16 weeks ACE gene was genotyped (PCR). Before and after 16 weeks, blood pressure (ambulatory), HDL-cholesterol, Total cholesterol, Glycemia, Triacylglycerol (colorimetric assay) and plasminogen activator inhibition (PAI-1), intercellular adhesion molecule (ICAM-1), vascular endothelial cell adhesion molecule (VCAM-1), Adiponectin, tumor necrosis factor alpha (TNF-alpha), C Reactive Protein, Angiotensin II, Angiotensin Converting Enzyme, Angiotensin 1-7, (ELISA assay) were measured.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hypertensives
- •Age 60 to 85 years
- •Nonactive
排除标准
- •Orthopedic problems or other problem that prevented the exercises
- •Change in drug treatment during protocol
- •Absence in more than 25% of the exercise sessions
结局指标
主要结局
Blood Pressure
时间窗: 16 weeks
Blood pressure was measured by Ambulatorial Monitoring Blood Pressure before and after 16 weeks of intervention.
次要结局
- Total Cholesterol(16 weeks)
- Glycemia(16 weeks)
- HDL-cholesterol(16 weeks)
- Triacylglycerol(16 weeks)
- PAI-1(16 weeks)
- ICAM-1(16 weeks)
- VCAM-1(16 weeks)
- Adiponectin(16 weeks)
- TNF alpha(16 weeks)
- C Reactive Protein(16 weeks)
- Angiotensin II(16 weeks)
- Angiotensin Converting Enzyme(16 weeks)
- Angiotensin 1-7(16 weeks)
研究者
Alessandra Medeiros
PhD
Federal University of São Paulo